Literature DB >> 20187240

The role of parkin in familial and sporadic Parkinson's disease.

Ted M Dawson1, Valina L Dawson.   

Abstract

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD.

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Year:  2010        PMID： 20187240      PMCID： PMC4115293          DOI： 10.1002/mds.22798

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  82 in total

1.  Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations.

Authors:  Meltem Müftüoglu; Bülent Elibol; Ozlem Dalmizrak; Ayse Ercan; Gülnihal Kulaksiz; Hamdi Ogüs; Turgay Dalkara; Nazmi Ozer
Journal:  Mov Disord       Date:  2004-05       Impact factor: 10.338

2.  Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones.

Authors:  Konstanze F Winklhofer; Iris H Henn; Penelope C Kay-Jackson; Ulrich Heller; Jörg Tatzelt
Journal:  J Biol Chem       Date:  2003-09-12       Impact factor: 5.157

3.  Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

Authors:  Aaron C Pawlyk; Benoit I Giasson; Deepak M Sampathu; Francisco A Perez; Kah Leong Lim; Valina L Dawson; Ted M Dawson; Richard D Palmiter; John Q Trojanowski; Virginia M-Y Lee
Journal:  J Biol Chem       Date:  2003-09-12       Impact factor: 5.157

4.  Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.

Authors:  Yakov Pesah; Tuan Pham; Heather Burgess; Brooke Middlebrooks; Patrik Verstreken; Yi Zhou; Mark Harding; Hugo Bellen; Graeme Mardon
Journal:  Development       Date:  2004-04-08       Impact factor: 6.868

5.  S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

Authors:  Kenny K K Chung; Bobby Thomas; Xiaojie Li; Olga Pletnikova; Juan C Troncoso; Laura Marsh; Valina L Dawson; Ted M Dawson
Journal:  Science       Date:  2004-04-22       Impact factor: 47.728

Review 6.  Genetics of parkin-linked disease.

Authors:  Andrew B West; Nigel T Maidment
Journal:  Hum Genet       Date:  2004-01-15       Impact factor: 4.132

7.  Parkin attenuates manganese-induced dopaminergic cell death.

Authors:  Youichirou Higashi; Masato Asanuma; Ikuko Miyazaki; Nobutaka Hattori; Yoshikuni Mizuno; Norio Ogawa
Journal:  J Neurochem       Date:  2004-06       Impact factor: 5.372

8.  Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

Authors:  Esti Liani; Allon Eyal; Eyal Avraham; Revital Shemer; Raymonde Szargel; Daniela Berg; Antje Bornemann; Olaf Riess; Christopher A Ross; Ruth Rott; Simone Engelender
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-02       Impact factor: 11.205

9.  Mitochondrial dysfunction and oxidative damage in parkin-deficient mice.

Authors:  James J Palacino; Dijana Sagi; Matthew S Goldberg; Stefan Krauss; Claudia Motz; Maik Wacker; Joachim Klose; Jie Shen
Journal:  J Biol Chem       Date:  2004-02-24       Impact factor: 5.157

10.  Hereditary early-onset Parkinson's disease caused by mutations in PINK1.

Authors:  Enza Maria Valente; Patrick M Abou-Sleiman; Viviana Caputo; Miratul M K Muqit; Kirsten Harvey; Suzana Gispert; Zeeshan Ali; Domenico Del Turco; Anna Rita Bentivoglio; Daniel G Healy; Alberto Albanese; Robert Nussbaum; Rafael González-Maldonado; Thomas Deller; Sergio Salvi; Pietro Cortelli; William P Gilks; David S Latchman; Robert J Harvey; Bruno Dallapiccola; Georg Auburger; Nicholas W Wood
Journal:  Science       Date:  2004-04-15       Impact factor: 47.728
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  132 in total

Review 1.  Recent advances in the genetics of Parkinson's disease.

Authors:  Ian Martin; Valina L Dawson; Ted M Dawson
Journal:  Annu Rev Genomics Hum Genet       Date:  2011       Impact factor: 8.929

Review 2.  Regulation of Parkin E3 ubiquitin ligase activity.

Authors:  Helen Walden; R Julio Martinez-Torres
Journal:  Cell Mol Life Sci       Date:  2012-04-19       Impact factor: 9.261

Review 3.  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences.

Authors:  Nicole Exner; Anne Kathrin Lutz; Christian Haass; Konstanze F Winklhofer
Journal:  EMBO J       Date:  2012-06-26       Impact factor: 11.598

Review 4.  Mechanisms of mitophagy.

Authors:  Richard J Youle; Derek P Narendra
Journal:  Nat Rev Mol Cell Biol       Date:  2011-01       Impact factor: 94.444

5.  Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells.

Authors:  Houbo Jiang; Yong Ren; Eunice Y Yuen; Ping Zhong; Mahboobe Ghaedi; Zhixing Hu; Gissou Azabdaftari; Kazuhiro Nakaso; Zhen Yan; Jian Feng
Journal:  Nat Commun       Date:  2012-02-07       Impact factor: 14.919

6.  Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Authors:  Diana K Costa; Brydie R Huckestein; Lia R Edmunds; Max C Petersen; Ali Nasiri; Gina M Butrico; Abudukadier Abulizi; Daniel B Harmon; Canying Lu; Benjamin S Mantell; Douglas J Hartman; João-Paulo G Camporez; Robert M O'Doherty; Gary W Cline; Gerald I Shulman; Michael J Jurczak
Journal:  Am J Physiol Endocrinol Metab       Date:  2016-05-10       Impact factor: 4.310

7.  PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

Authors:  Joo-Ho Shin; Han Seok Ko; Hochul Kang; Yunjong Lee; Yun-Il Lee; Olga Pletinkova; Juan C Troconso; Valina L Dawson; Ted M Dawson
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

Review 8.  Microglia and astrocyte dysfunction in parkinson's disease.

Authors:  Tae-In Kam; Jared T Hinkle; Ted M Dawson; Valina L Dawson
Journal:  Neurobiol Dis       Date:  2020-07-28       Impact factor: 5.996

9.  Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.

Authors:  Sébastien Brot; Carole Auger; Rabia Bentata; Véronique Rogemond; Stéphane Ménigoz; Naura Chounlamountri; Agnès Girard-Egrot; Jérôme Honnorat; Mahnaz Moradi-Améli
Journal:  J Biol Chem       Date:  2013-12-09       Impact factor: 5.157

10.  S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease.

Authors:  Chun-Tao Yang; Nelmi O Devarie-Baez; Akil Hamsath; Xiao-Dong Fu; Ming Xian
Journal:  Antioxid Redox Signal       Date:  2019-10-25       Impact factor: 8.401
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