Literature DB >> 1216339

Determination of the acetylator phenotype using matrix isoniazid.

G A Ellard, P T Gammon, H Titinen.   

Abstract

The development of a simple method for classifying subjects as slow or rapid acetylators is reported. The method is based on determining the ratio of acetylisoniazid to acid-labile isoniazid in the urine 23-24 hours after an oral dose of a slow-release isoniazid formulation. The results obtained when this method was applied to phenotype over 200 East African tuberculosis patients are described. It is suggested that the method would be particularly suitable for classifying tuberculosis out-patients.

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Year:  1975        PMID： 1216339     DOI： 10.1016/0041-3879(75)90053-7

Source DB:  PubMed          Journal:  Tubercle        ISSN： 0041-3879


  9 in total

Review 1.  Ethnic differences in drug disposition and responsiveness.

Authors:  A J Wood; H H Zhou
Journal:  Clin Pharmacokinet       Date:  1991-05       Impact factor: 6.447

2.  Pharmacokinetics of isoniazid metabolism in man.

Authors:  G A Ellard; P T Gammon
Journal:  J Pharmacokinet Biopharm       Date:  1976-04

3.  Human acetylator polymorphism: estimate of allele frequency in Libya and details of global distribution.

Authors:  A K Karim; M S Elfellah; D A Evans
Journal:  J Med Genet       Date:  1981-10       Impact factor: 6.318

4.  Polymorphic acetylation of sulphamethazine in a Zimbabwe population.

Authors:  C F Nhachi
Journal:  J Med Genet       Date:  1988-01       Impact factor: 6.318

Review 5.  Survey of the human acetylator polymorphism in spontaneous disorders.

Authors:  D A Evans
Journal:  J Med Genet       Date:  1984-08       Impact factor: 6.318

6.  Acetylation polymorphism and leprosy.

Authors:  L C Eze; A N Okpogba; A U Ogan
Journal:  Biochem Genet       Date:  1990-02       Impact factor: 1.890

7.  The association of the slow acetylator phenotype with bladder cancer.

Authors:  D A Evans; L C Eze; E J Whibley
Journal:  J Med Genet       Date:  1983-10       Impact factor: 6.318

Review 8.  Clinical pharmacokinetics of isoniazid.

Authors:  W W Weber; D W Hein
Journal:  Clin Pharmacokinet       Date:  1979 Nov-Dec       Impact factor: 6.447

9.  Acetylator phenotyping of tuberculosis patients using matrix isoniazid or sulphadimidine and its prognostic significance for treatment with several intermittent isoniazid-containing regimens.

Authors:  G A Ellard; P T Gammon
Journal:  Br J Clin Pharmacol       Date:  1977-02       Impact factor: 4.335
  9 in total

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