| Literature DB >> 12161162 |
Achyutharao Sidduri1, Jefferson W Tilley, Jian Ping Lou, Li Chen, Gerry Kaplan, Frank Mennona, Robert Campbell, Robert Guthrie, Tai-Nan Huang, Karen Rowan, Virginia Schwinge, Louis M Renzetti.
Abstract
A series of N-benzoyl-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine derivatives was prepared in order to optimize the substitution on the N-benzoyl moiety for VCAM/VLA-4 antagonist activity. Disubstitution in the 2- and 6-positions is favored and a range of small alkyl and halogen are tolerated. A model of the bioactive conformation of these compounds is proposed.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12161162 DOI： 10.1016/s0960-894x(02)00387-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823