Literature DB >> 12161156

Synthesis of cholesterol-carborane conjugate for targeted drug delivery.

Bingqing Ji1, Gina Peacock, D Robert Lu.   

Abstract

The cholesterol-carborane conjugate has been designed and synthesized to selectively deliver boron to tumor cells by means of reconstituted low-density lipoprotein. The chemical stability and cytotoxicity of the new compound have been examined. Several methods have been evaluated for incorporation of the compound into LDL.

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Year:  2002        PMID： 12161156     DOI： 10.1016/s0960-894x(02)00426-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents.

Authors:  Subash C Jonnalagadda; Jonathan S Cruz; Ryan J Connell; Patricia M Scott; Venkatram R Mereddy
Journal:  Tetrahedron Lett       Date:  2009-07-29       Impact factor: 2.415

2.  Uptake of the carborane derivative of cholesteryl ester by glioma cancer cells is mediated through LDL receptors.

Authors:  Guangliang Pan; Svein Oie; D Robert Lu
Journal:  Pharm Res       Date:  2004-07       Impact factor: 4.200

3.  Low Density Lipid Nanoparticles for Solid Tumor Targeting.

Authors:  Mayank Shrivastava; Aviral Jain; Arvind Gulbake; Pooja Hurkat; Neeti Jain; R Vijayraghwan; Sanjay K Jain
Journal:  Sci Pharm       Date:  2014-08-28

4.  Recombinant high-density lipoprotein nanoparticles containing gadolinium-labeled cholesterol for morphologic and functional magnetic resonance imaging of the liver.

Authors:  Mengjie Rui; Wei Guo; Qian Ding; Xiaohui Wei; Jianrong Xu; Yuhong Xu
Journal:  Int J Nanomedicine       Date:  2012-07-17

Review 5.  Reconfiguring Nature's Cholesterol Accepting Lipoproteins as Nanoparticle Platforms for Transport and Delivery of Therapeutic and Imaging Agents.

Authors:  Skylar T Chuang; Siobanth Cruz; Vasanthy Narayanaswami
Journal:  Nanomaterials (Basel)       Date:  2020-05-08       Impact factor: 5.076
  5 in total

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