Literature DB >> 12161120

Antimalarial activity of ferrocenyl chalcones.

Xiang Wu1, Prapon Wilairat, Mei-Lin Go.   

Abstract

A series of ferrocenyl chalcones were synthesized and evaluated for in vitro antimalarial activity against a chloroquine-resistant strain of Plasmodium falciparum. The most active compounds were 1-(3-pyridyl)-3-ferrocenyl-2-propen-1-one (6) and 1-ferrocenyl-3-(4-nitrophenyl)-2-propen-1-one (28) with IC(50) of 4.5 and 5.1 microM, respectively. Differences in activity were not readily explained by the size and lipophilicity characteristics of these compounds.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12161120     DOI： 10.1016/s0960-894x(02)00430-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  The synthesis, X-ray crystal structure and optical properties of novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline derivatives.

Authors:  Zhong-Liang Gong; Yong-Sheng Xie; Bao-Xiang Zhao; Hong-Shui Lv; Wei-Yong Liu; Liang-Wen Zheng; Song Lian
Journal:  J Fluoresc       Date:  2010-10-02       Impact factor: 2.217

2.  Synthesis and characterization of novel ferrocenyl chalcone ammonium and pyridinium salt derivatives.

Authors:  Sara M Delgado-Rivera; Giovanny E Pérez-Ortiz; Andrés Molina-Villarino; Fabiel Morales-Fontán; Lyannis M García-Santos; Alma M González-Albó; Ana R Guadalupe; Ingrid Montes-González
Journal:  Inorganica Chim Acta       Date:  2017-07-01       Impact factor: 2.545

3.  (E)-3-Ferrocenyl-1-(2-hy-droxy-phen-yl)-prop-2-en-1-one.

Authors:  C Valdebenito; M T Garland; M Fuentealba; C A Escobar
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-23

Review 4.  Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review.

Authors:  Mamdouh F A Mohamed; Gamal El-Din A Abuo-Rahma
Journal:  RSC Adv       Date:  2020-08-21       Impact factor: 4.036

5.  ZnO Catalyzed Efficient Synthesis of Some New 2-Substituted-4,6-diarylpyrimidines.

Authors:  K L Ameta; Biresh Kumar; Nitu S Rathore
Journal:  ISRN Org Chem       Date:  2012-10-15

6.  A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives.

Authors:  Yasser H Zaki; Marwa S Al-Gendey; Abdou O Abdelhamid
Journal:  Chem Cent J       Date:  2018-06-20       Impact factor: 4.215

Review 7.  Ferrocene-Based Compounds with Antimalaria/Anticancer Activity.

Authors:  Sijongesonke Peter; Blessing Atim Aderibigbe
Journal:  Molecules       Date:  2019-10-07       Impact factor: 4.411

8.  1H-1,2,3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation.

Authors:  Kewal Kumar; Bruno Pradines; Marilyn Madamet; Rémy Amalvict; Nicolas Benoit; Vipan Kumar
Journal:  Eur J Med Chem       Date:  2014-10-13       Impact factor: 6.514

9.  Microwave Assisted Synthesis, Characterization and Biological Activities of Ferrocenyl Chalcones and Their QSAR Analysis.

Authors:  Dinesh K Yadav; Parshant Kaushik; Virendra S Rana; Deeba Kamil; Dilip Khatri; Najam A Shakil
Journal:  Front Chem       Date:  2019-11-26       Impact factor: 5.221

Review 10.  Ferrocene conjugates of chloroquine and other antimalarials: the development of ferroquine, a new antimalarial.

Authors:  Daniel Dive; Christophe Biot
Journal:  ChemMedChem       Date:  2008-03       Impact factor: 3.466
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.