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Literature DB >> 12161064

1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives.

Pascal Rathelot¹, Nadine Azas, Hussein El-Kashef, Florence Delmas, Carole Di Giorgio, Pierre Timon-David, José Maldonado, Patrice Vanelle.

Abstract

1,3-Diphenylpyrazole-4-carboxaldehyde and 1-(4-nitrophenyl)-3-phenylpyrazole-4-carboxaldehyde were obtained from the appropriated phenylhydrazones via the Vilsmeier-Haack reaction. These two aldehydes were functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed. In the most cases, nitrated compounds were found to be more efficient than non-nitrated ones against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum.

Entities: Chemical Species

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Year: 2002 PMID： 12161064 DOI： 10.1016/s0223-5234(02)01388-0

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

13 in total

1. Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.

Authors: Alireza Hasaninejad; Somayeh Firoozi
Journal: Mol Divers Date: 2013-04-27 Impact factor: 2.943

2. Combinatorial synthesis of chemical building blocks 1. Azomethines.

Authors: Sergey V Ryabukhin; Dmitriy M Panov; Andrey S Plaskon; Alexander Chuprina; Sergey E Pipko; Andrey A Tolmachev; Alexander N Shivanyuk
Journal: Mol Divers Date: 2012-10-30 Impact factor: 2.943

3. Synthesis and fungicidal activity of phenylhydrazone derivatives containing two carbonic acid ester groups.

Authors: Jun-Jun Wang; Wei-Jie Si; Min Chen; Ai-Min Lu; Wei-Hua Zhang; Chun-Long Yang
Journal: J Pestic Sci Date: 2017-08-20 Impact factor: 1.519

4. Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells.

Authors: Mahavir Chhajed; Anil Kumar Shrivastava; Vijay Taile
Journal: Med Chem Res Date: 2013-12-27 Impact factor: 1.965

1,3-Diphenylpyrazoles: synthesis and antiparasitic activities of azomethine derivatives.

1. Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.

2. Combinatorial synthesis of chemical building blocks 1. Azomethines.

3. Synthesis and fungicidal activity of phenylhydrazone derivatives containing two carbonic acid ester groups.

4. Synthesis of 5-arylidine amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamides endowed with potent antioxidants and anticancer activity induces growth inhibition in HEK293, BT474 and NCI-H226 cells.

5. Antileishmanial, antimicrobial and antifungal activities of some new aryl azomethines.

6. Synthesis of novel 1-[(2,6-dichloro-4-trifluoromethyl)phenyl]-3-aryl-1H-pyrazole-4-carbaldehydes.

7. Pyridine-based heterocycles. Synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles.

8. Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole.

9. 3-(4-Bromo-phen-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde.

10. Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents.