PURPOSE: To describe the cross-sectional association of counts of total and subtypes of leukocytes, platelets, and selected characteristics of red blood cells with intensity of cigarette smoking and smoking cessation. METHODS: The study population consisted of 16,254 men and women 20-70 years of age who participated in the Dutch European Prospective Investigation into Cancer and nutrition (EPIC) subcohort, 1995-1997. Linear regression analysis was performed, for both sexes separately, to study the relation between various measurements of smoking habits and hematologic characteristics. RESULTS: Among current smokers, in both genders, packyears and daily number of cigarettes were associated with increased leukocytes (6-19%), lymphocytes (4-14%), monocytes (3-9%), neutrophils (7-24%), platelets (1-5%), mean corpuscular volume (0.4-2%), hematocrit (0.3-4%), hemoglobin (0.3-4%), and mean corpuscular hemoglobin (0.8-2%). In subjects who had quit smoking within two years before blood measurement, hematological characteristics in most cells were similar as in never smokers, whereas normal counts of lymphocytes and monocytes were observed only 2-5 years after quitting. CONCLUSIONS: Our findings suggest a marked influence of current smoking habits on leukocyte counts and, to a lesser extent, on counts of erythrocytes and platelets. Following smoking cessation, at least five years have to pass before changes in all hematological parameters may return to normal values.
PURPOSE: To describe the cross-sectional association of counts of total and subtypes of leukocytes, platelets, and selected characteristics of red blood cells with intensity of cigarette smoking and smoking cessation. METHODS: The study population consisted of 16,254 men and women 20-70 years of age who participated in the Dutch European Prospective Investigation into Cancer and nutrition (EPIC) subcohort, 1995-1997. Linear regression analysis was performed, for both sexes separately, to study the relation between various measurements of smoking habits and hematologic characteristics. RESULTS: Among current smokers, in both genders, packyears and daily number of cigarettes were associated with increased leukocytes (6-19%), lymphocytes (4-14%), monocytes (3-9%), neutrophils (7-24%), platelets (1-5%), mean corpuscular volume (0.4-2%), hematocrit (0.3-4%), hemoglobin (0.3-4%), and mean corpuscular hemoglobin (0.8-2%). In subjects who had quit smoking within two years before blood measurement, hematological characteristics in most cells were similar as in never smokers, whereas normal counts of lymphocytes and monocytes were observed only 2-5 years after quitting. CONCLUSIONS: Our findings suggest a marked influence of current smoking habits on leukocyte counts and, to a lesser extent, on counts of erythrocytes and platelets. Following smoking cessation, at least five years have to pass before changes in all hematological parameters may return to normal values.
Authors: Luigi Di Lorenzo; Andrea Silvestroni; Maria Giuliana Martino; Tommaso Gagliardi; Marisa Corfiati; Leonardo Soleo Journal: Int Arch Occup Environ Health Date: 2006-01-17 Impact factor: 3.015
Authors: Dorothy K Hatsukami; Xianghua Luo; Alisa K Heskin; Mei Kuen Tang; Steven G Carmella; Joni Jensen; Jason D Robinson; Ryan Vandrey; David J Drobes; Andrew A Strasser; Mustafa al'Absi; Scott Leischow; Paul M Cinciripini; Joseph Koopmeiners; Joshua Ikuemonisan; Neal L Benowitz; Eric C Donny; Stephen S Hecht Journal: Addiction Date: 2019-07-08 Impact factor: 6.526
Authors: Paloma Domínguez Ruiz de León; Victoria Morcillo Cebolla; Blanca Gutiérrez Parres; Francisco Javier Cirujano Pita; Elvira Díaz de Tuesta Díaz de Lezama; Elena Mazorra Benito Journal: Aten Primaria Date: 2010-07-08 Impact factor: 1.137
Authors: Kristina A Williams; S Intidhar Labidi-Galy; Kathryn L Terry; Allison F Vitonis; William R Welch; Annekathryn Goodman; Daniel W Cramer Journal: Gynecol Oncol Date: 2014-01-23 Impact factor: 5.482
Authors: David R Colquhoun; Lynn R Goldman; Robert N Cole; Marjan Gucek; Malini Mansharamani; Frank R Witter; Benjamin J Apelberg; Rolf U Halden Journal: Environ Health Perspect Date: 2008-12-02 Impact factor: 9.031