BACKGROUND: Several cardiovascular disease (CVD) biomarkers sensitive to tobacco exposure have been identified, but how tobacco use cessation impacts them is less clear. We sought to investigate the effects of a smoking cessation program with an exercise intervention on CVD biomarkers in sedentary women. METHODS: This is a cohort study on a subsample of a 2×2 factorial randomized controlled trial (RCT) (exercise setting: home vs. facility; level of exercise counseling: prescription only vs. prescription and adherence counseling) conducted January 2004 through December 2007. The analyses were completed in October 2010. In the greater Boston area, 130 sedentary female smokers aged 19-55 completed a 15-week program. All participants received nicotine replacement therapy (transdermal patch) and brief behavioral counseling for 12 weeks. They all received an exercise prescription on a moderate intensity level. All exercise interventions lasted for 15 weeks, from 3 weeks precessation until 12 weeks postcessation. Main outcome measures were selected CVD biomarkers hypothesized to be affected by smoking cessation or exercise measured at baseline and 12 weeks postcessation. RESULTS: Independent of tobacco abstinence, improvement was seen in inflammation (white blood cells [WBC]), prothrombotic factor (red blood cells [RBC]), and cardiovascular fitness level (maximum oxygen consumption [Vo(2)max]). This suggests that even if complete abstinence is not achieved, reduction in tobacco exposure and increase in exercise can improve the cardiovascular risk profile. A significant decrease was seen for total cholesterol and the total cholesterol high-density lipoprotein cholesterol (HDL-C): ratio only among the abstainers. The heart rate was reduced among all participants, but this decrease was more profound among abstainers. A significant weight gain and body mass index (BMI) increase were observed among abstainers and those who relapsed. We also found an increase in hemoglobinA1c (Hb A1c), although significant only when the groups were combined. CONCLUSIONS: A smoking cessation intervention including exercise reduced tobacco-induced cardiovascular damage selectively within 3 months.
RCT Entities:
BACKGROUND: Several cardiovascular disease (CVD) biomarkers sensitive to tobacco exposure have been identified, but how tobacco use cessation impacts them is less clear. We sought to investigate the effects of a smoking cessation program with an exercise intervention on CVD biomarkers in sedentary women. METHODS: This is a cohort study on a subsample of a 2×2 factorial randomized controlled trial (RCT) (exercise setting: home vs. facility; level of exercise counseling: prescription only vs. prescription and adherence counseling) conducted January 2004 through December 2007. The analyses were completed in October 2010. In the greater Boston area, 130 sedentary female smokers aged 19-55 completed a 15-week program. All participants received nicotine replacement therapy (transdermal patch) and brief behavioral counseling for 12 weeks. They all received an exercise prescription on a moderate intensity level. All exercise interventions lasted for 15 weeks, from 3 weeks precessation until 12 weeks postcessation. Main outcome measures were selected CVD biomarkers hypothesized to be affected by smoking cessation or exercise measured at baseline and 12 weeks postcessation. RESULTS: Independent of tobacco abstinence, improvement was seen in inflammation (white blood cells [WBC]), prothrombotic factor (red blood cells [RBC]), and cardiovascular fitness level (maximum oxygen consumption [Vo(2)max]). This suggests that even if complete abstinence is not achieved, reduction in tobacco exposure and increase in exercise can improve the cardiovascular risk profile. A significant decrease was seen for total cholesterol and the total cholesterol high-density lipoprotein cholesterol (HDL-C): ratio only among the abstainers. The heart rate was reduced among all participants, but this decrease was more profound among abstainers. A significant weight gain and body mass index (BMI) increase were observed among abstainers and those who relapsed. We also found an increase in hemoglobin A1c (Hb A1c), although significant only when the groups were combined. CONCLUSIONS: A smoking cessation intervention including exercise reduced tobacco-induced cardiovascular damage selectively within 3 months.
Authors: Benjamin D Horne; Jeffrey L Anderson; Jerry M John; Aaron Weaver; Tami L Bair; Kurt R Jensen; Dale G Renlund; Joseph B Muhlestein Journal: J Am Coll Cardiol Date: 2005-04-25 Impact factor: 24.094
Authors: William E Kraus; Joseph A Houmard; Brian D Duscha; Kenneth J Knetzger; Michelle B Wharton; Jennifer S McCartney; Connie W Bales; Sarah Henes; Gregory P Samsa; James D Otvos; Krishnaji R Kulkarni; Cris A Slentz Journal: N Engl J Med Date: 2002-11-07 Impact factor: 91.245
Authors: Danielle E McCarthy; Thomas M Piasecki; Daniel L Lawrence; Douglas E Jorenby; Saul Shiffman; Timothy B Baker Journal: Addiction Date: 2008-09 Impact factor: 6.526
Authors: John R Hughes; Josue P Keely; Ray S Niaura; Deborah J Ossip-Klein; Robyn L Richmond; Gary E Swan Journal: Nicotine Tob Res Date: 2003-02 Impact factor: 4.244
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Authors: Samantha G Farris; Michelle L Davis; David Rosenfield; Brooke Y Kauffman; Scarlett O Baird; Mark B Powers; Michael W Otto; Bess H Marcus; Timothy S Church; Jasper A J Smits; Michael J Zvolensky Journal: Ment Health Phys Act Date: 2016-05-10
Authors: Abdulhamied Alfaddagh; Seth S Martin; Thorsten M Leucker; Erin D Michos; Michael J Blaha; Charles J Lowenstein; Steven R Jones; Peter P Toth Journal: Am J Prev Cardiol Date: 2020-11-21
Authors: Allan Linneberg; Rikke K Jacobsen; Tea Skaaby; Amy E Taylor; Meg E Fluharty; Jørgen L Jeppesen; Johan H Bjorngaard; Bjørn O Åsvold; Maiken E Gabrielsen; Archie Campbell; Riccardo E Marioni; Meena Kumari; Pedro Marques-Vidal; Marika Kaakinen; Alana Cavadino; Iris Postmus; Tarunveer S Ahluwalia; S Goya Wannamethee; Jari Lahti; Katri Räikkönen; Aarno Palotie; Andrew Wong; Christine Dalgård; Ian Ford; Yoav Ben-Shlomo; Lene Christiansen; Kirsten O Kyvik; Diana Kuh; Johan G Eriksson; Peter H Whincup; Hamdi Mbarek; Eco J C de Geus; Jacqueline M Vink; Dorret I Boomsma; George Davey Smith; Debbie A Lawlor; Aliaksei Kisialiou; Alex McConnachie; Sandosh Padmanabhan; J Wouter Jukema; Chris Power; Elina Hyppönen; Martin Preisig; Gerard Waeber; Peter Vollenweider; Tellervo Korhonen; Tiina Laatikainen; Veikko Salomaa; Jaakko Kaprio; Mika Kivimaki; Blair H Smith; Caroline Hayward; Thorkild I A Sørensen; Betina H Thuesen; Naveed Sattar; Richard W Morris; Pål R Romundstad; Marcus R Munafò; Marjo-Riitta Jarvelin; Lise Lotte N Husemoen Journal: Circ Cardiovasc Genet Date: 2015-11-04