| Literature DB >> 12153119 |
Akira Nishizono1, Kazuaki Mannen, Luningning P Elio-Villa, Seiichi Tanaka, Kang-sheng Li, Kumato Mifune, Benito F Arca, Arturo Cabanban, Benjamin Martinez, Arlito Rodriguez, Victor C Atienza, Rolando Camba, Nilo Resontoc.
Abstract
To determine the genetic characteristics of the rabies virus in the Philippines, 59 rabies virus isolates were obtained from domestic rabid dogs and their partial nucleotide sequences of nucleoprotein (N) gene were compared. Based on comparison with reported sequences, phylogenetic analysis revealed that all isolates from the Philippines had close genetic relations and formed two subgroups. The Philippines isolates belonged to a different lineage from other Asian isolates but were closer to them than to terrestrial isolates and laboratory strains. Several specific nucleotide and amino acid substitutions were observed among the Philippines isolates. Our results suggest that rabies viruses in the Philippines might have a characteristic evolution.Entities:
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Year: 2002 PMID: 12153119 DOI: 10.1111/j.1348-0421.2002.tb02714.x
Source DB: PubMed Journal: Microbiol Immunol ISSN: 0385-5600 Impact factor: 1.955