Literature DB >> 12150868

Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium.

Kou Hiroya1, Taisuke Takahashi, Nobuhiko Miura, Akira Naganuma, Takao Sakamoto.   

Abstract

The protecting effect of betulin against cadmium toxicity was investigated using 11 kinds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.

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Year:  2002        PMID： 12150868     DOI： 10.1016/s0968-0896(02)00172-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Study of the betulin molecule in a water environment; ab initio and molecular simulation calculations.

Authors:  Miroslav Pospíšil; Petr Kovář; Robert Vácha; Michal Svoboda
Journal:  J Mol Model       Date:  2011-05-03       Impact factor: 1.810

Review 2.  New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity.

Authors:  Ewa Bębenek; Monika Kadela-Tomanek; Elwira Chrobak; Joanna Wietrzyk; Joanna Sadowska; Stanisław Boryczka
Journal:  Med Chem Res       Date:  2016-09-01       Impact factor: 1.965

3.  Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer.

Authors:  George R Pettit; Noeleen Melody; Frank Hempenstall; Jean-Charles Chapuis; Thomas L Groy; Lee Williams
Journal:  J Nat Prod       Date:  2014-04-02       Impact factor: 4.050
  3 in total

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