| Literature DB >> 12142529 |
Jafar Mahdavi1, Berit Sondén, Marina Hurtig, Farzad O Olfat, Lina Forsberg, Niamh Roche, Jonas Angstrom, Thomas Larsson, Susann Teneberg, Karl-Anders Karlsson, Siiri Altraja, Torkel Wadström, Dangeruta Kersulyte, Douglas E Berg, Andre Dubois, Christoffer Petersson, Karl-Eric Magnusson, Thomas Norberg, Frank Lindh, Bertil B Lundskog, Anna Arnqvist, Lennart Hammarström, Thomas Borén.
Abstract
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.Entities:
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Year: 2002 PMID： 12142529 PMCID： PMC2570540 DOI： 10.1126/science.1069076
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728