Literature DB >> 12141855

Three novel protease inhibitors from a natural bloom of the cyanobacterium Microcystis aeruginosa.

Alexei Ploutno1, Maria Shoshan, Shmuel Carmeli.   

Abstract

Two new trypsin inhibitors, micropeptins EI992 (1) and EI964 (2), and a modified linear peptide aeruginosin EI461 (3) were isolated from the hydrophilic extract of two samples of Microcystis aeruginosa, collected from the Einan Reservoir in Israel. Homonuclear and heteronuclear 2D-NMR techniques as well as HRFABMS determined the gross structures of 1-3. The relative and absolute stereochemistry of 1-3 was deduced by a combination of spectral data and Marfey's method for HPLC. Aeruginosin EI461 (3) differs from the 14 known aeruginosins in the relative and absolute stereochemistry of the Choi-6-hydroxyl substituent.

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Year:  2002        PMID： 12141855     DOI： 10.1021/np010597b

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.

Authors:  Roger G Linington; Daniel J Edwards; Cynthia F Shuman; Kerry L McPhail; Teatulohi Matainaho; William H Gerwick
Journal:  J Nat Prod       Date:  2007-12-29       Impact factor: 4.050

Review 2.  Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

Authors:  George E Chlipala; Shunyan Mo; Jimmy Orjala
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

3.  Investigation of antimicrobial and protease-inhibitory activity from cultured cyanobacteria.

Authors:  George Chlipala; Shunyan Mo; Esperanza J Carcache de Blanco; Aiko Ito; Stanley Bazarek; Jimmy Orjala
Journal:  Pharm Biol       Date:  2009-01       Impact factor: 3.503

4.  Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides.

Authors:  Jason C Kwan; Ranjala Ratnayake; Khalil A Abboud; Valerie J Paul; Hendrik Luesch
Journal:  J Org Chem       Date:  2010-11-04       Impact factor: 4.354

5.  Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates.

Authors:  Joshua G Pierce; Dhanalakshmi Kasi; Makoto Fushimi; Anthony Cuzzupe; Peter Wipf
Journal:  J Org Chem       Date:  2008-09-04       Impact factor: 4.354

6.  Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8.

Authors:  Hilary S Okumura; Benjamin Philmus; Cyril Portmann; Thomas K Hemscheidt
Journal:  J Nat Prod       Date:  2009-01       Impact factor: 4.050

Review 7.  Targeting eukaryotic proteases for natural products-based drug development.

Authors:  Fatma H Al-Awadhi; Hendrik Luesch
Journal:  Nat Prod Rep       Date:  2020-06-24       Impact factor: 13.423

8.  Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena.

Authors:  Jason C Kwan; Kanchan Taori; Valerie J Paul; Hendrik Luesch
Journal:  Mar Drugs       Date:  2009-11-03       Impact factor: 5.118

9.  Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety.

Authors:  Keishi Ishida; Guntram Christiansen; Wesley Y Yoshida; Rainer Kurmayer; Martin Welker; Nativitat Valls; Josep Bonjoch; Christian Hertweck; Thomas Börner; Thomas Hemscheidt; Elke Dittmann
Journal:  Chem Biol       Date:  2007-05

10.  Diversity of peptides produced by Nodularia spumigena from various geographical regions.

Authors:  Hanna Mazur-Marzec; Monika J Kaczkowska; Agata Blaszczyk; Reyhan Akcaalan; Lisa Spoof; Jussi Meriluoto
Journal:  Mar Drugs       Date:  2012-12-21       Impact factor: 5.118
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