BACKGROUND: Percutaneous closure of the patent foramen ovale (PFO) is usually performed under x-ray in combination with ultrasound guidance. We tested the feasibility of applying magnetic resonance (MR) guidance for percutaneous closure of PFO in an animal model, thus avoiding the disadvantage of ionizing radiation. METHODS AND RESULTS: Real-time MRI with radial or spiral k-space filling (15 frames per second) on an interventional 1.5-T high-field whole-body system was exploited to examine the feasibility of MR-guided closure of the PFO in 7 piglets weighing approximately 14 kg. A specially designed prototype nonmagnetic closure device was introduced via the femoral vein. The short bore of the magnet and in-room monitors allowed for visualization and steering of the catheter with the loaded occluder. Catheterization of the left atrium and, finally, correct placement of the device was possible in all animals. Deployment of the device was depicted by real-time MR, and initial misplacement, which occurred in 2 animals, was easily detected and corrected. CONCLUSIONS: Real-time MR guidance of PFO closure, without the use of ionizing radiation, is feasible in an animal model.
BACKGROUND: Percutaneous closure of the patent foramen ovale (PFO) is usually performed under x-ray in combination with ultrasound guidance. We tested the feasibility of applying magnetic resonance (MR) guidance for percutaneous closure of PFO in an animal model, thus avoiding the disadvantage of ionizing radiation. METHODS AND RESULTS: Real-time MRI with radial or spiral k-space filling (15 frames per second) on an interventional 1.5-T high-field whole-body system was exploited to examine the feasibility of MR-guided closure of the PFO in 7 piglets weighing approximately 14 kg. A specially designed prototype nonmagnetic closure device was introduced via the femoral vein. The short bore of the magnet and in-room monitors allowed for visualization and steering of the catheter with the loaded occluder. Catheterization of the left atrium and, finally, correct placement of the device was possible in all animals. Deployment of the device was depicted by real-time MR, and initial misplacement, which occurred in 2 animals, was easily detected and corrected. CONCLUSIONS: Real-time MR guidance of PFO closure, without the use of ionizing radiation, is feasible in an animal model.
Authors: Venkatesh K Raman; Parag V Karmarkar; Michael A Guttman; Alexander J Dick; Dana C Peters; Cengizhan Ozturk; Breno S S Pessanha; Richard B Thompson; Amish N Raval; Ranil DeSilva; Ronnier J Aviles; Ergin Atalar; Elliot R McVeigh; Robert J Lederman Journal: J Am Coll Cardiol Date: 2005-06-21 Impact factor: 24.094
Authors: Amish N Raval; Parag V Karmarkar; Michael A Guttman; Cengizhan Ozturk; Ranil Desilva; Ronnier J Aviles; Victor J Wright; William H Schenke; Ergin Atalar; Elliot R McVeigh; Robert J Lederman Journal: Catheter Cardiovasc Interv Date: 2006-04 Impact factor: 2.692
Authors: Amish N Raval; Parag V Karmarkar; Michael A Guttman; Cengizhan Ozturk; Smita Sampath; Ranil DeSilva; Ronnier J Aviles; Minnan Xu; Victor J Wright; William H Schenke; Ozgur Kocaturk; Alexander J Dick; Venkatesh K Raman; Ergin Atalar; Elliot R McVeigh; Robert J Lederman Journal: Circulation Date: 2006-02-20 Impact factor: 29.690
Authors: R Corti; J Badimon; G Mizsei; F Macaluso; M Lee; P Licato; J F Viles-Gonzalez; V Fuster; W Sherman Journal: Heart Date: 2005-03 Impact factor: 5.994
Authors: Alexander J Dick; Michael A Guttman; Venkatesh K Raman; Dana C Peters; Breno S S Pessanha; Jonathan M Hill; Scott Smith; Greig Scott; Elliot R McVeigh; Robert J Lederman Journal: Circulation Date: 2003-12-01 Impact factor: 29.690