Literature DB >> 12135769

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.

Jian-Ming Guo1, Yan Zhang, Lamei Cheng, Hiroko Iwasaki, Han Wang, Tomomi Kubota, Kouichi Tachibana, Hisashi Narimatsu.   

Abstract

We cloned in silico a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T), pp-GalNAc-T12. The deduced amino acid sequence of pp-GalNAc-T12 contains all conserved motifs in pp-GalNAc-T family proteins. Quantitative real time polymerase chain reaction analysis revealed that the pp-GalNAc-T12 transcript was expressed mainly in digestive organs such as stomach, small intestine and colon. The recombinant pp-GalNAc-T12 transferred GalNAc to the mucin-derived peptides such as the Muc1a, Muc5AC, EA2 peptides and the GalNAc-Muc5AC glycopeptide. Since mucins are glycoproteins mainly produced in the digestive organs, our results suggest that pp-GalNAc-T12 plays an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.

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Year:  2002        PMID： 12135769     DOI： 10.1016/s0014-5793(02)03007-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

1.  Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Authors:  Yun Kong; Hiren J Joshi; Katrine Ter-Borch Gram Schjoldager; Thomas Daugbjerg Madsen; Thomas A Gerken; Malene B Vester-Christensen; Hans H Wandall; Eric Paul Bennett; Steven B Levery; Sergey Y Vakhrushev; Henrik Clausen
Journal:  Glycobiology       Date:  2014-08-25       Impact factor: 4.313

2.  A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.

Authors:  Kathryn S Higginbotham; Joan P Breyer; Kate M McReynolds; Kevin M Bradley; Peggy A Schuyler; W Dale Plummer; Marcia E Freudenthal; Amy Trentham-Dietz; Polly A Newcomb; Fritz F Parl; Melinda E Sanders; David L Page; Kathleen M Egan; William D Dupont; Jeffrey R Smith
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2012-07-17       Impact factor: 4.254

3.  Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.

Authors:  Thomas A Gerken; Oliver Jamison; Cynthia L Perrine; Jeremy C Collette; Helen Moinova; Lakshmeswari Ravi; Sanford D Markowitz; Wei Shen; Himatkumar Patel; Lawrence A Tabak
Journal:  J Biol Chem       Date:  2011-02-24       Impact factor: 5.157

Review 4.  Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Authors:  Eric P Bennett; Ulla Mandel; Henrik Clausen; Thomas A Gerken; Timothy A Fritz; Lawrence A Tabak
Journal:  Glycobiology       Date:  2011-12-18       Impact factor: 4.313

5.  Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs.

Authors:  Thomas A Gerken; Kelly G Ten Hagen; Oliver Jamison
Journal:  Glycobiology       Date:  2008-07-31       Impact factor: 4.313

6.  Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.

Authors:  Joana Gomes; Nuno T Marcos; Nora Berois; Eduardo Osinaga; Ana Magalhães; João Pinto-de-Sousa; Raquel Almeida; Fátima Gärtner; Celso A Reis
Journal:  J Histochem Cytochem       Date:  2008-10-14       Impact factor: 2.479

7.  N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry.

Authors:  Chen Wu; Xiaodan Guo; Weina Wang; Yun Wang; Yaojun Shan; Bo Zhang; Wenqian Song; Sisi Ma; Jianfeng Ge; Hao Deng; Mingsheng Zhu
Journal:  BMC Cancer       Date:  2010-04-01       Impact factor: 4.430

Review 8.  Recent insights into the biological roles of mucin-type O-glycosylation.

Authors:  E Tian; Kelly G Ten Hagen
Journal:  Glycoconj J       Date:  2008-08-10       Impact factor: 2.916

9.  Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus.

Authors:  Teresa Freire; Cecilia Fernández; Cora Chalar; Rick M Maizels; Pedro Alzari; Eduardo Osinaga; Carlos Robello
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

10.  Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.

Authors:  Kishore Guda; Helen Moinova; Jian He; Oliver Jamison; Lakshmeswari Ravi; Leanna Natale; James Lutterbaugh; Earl Lawrence; Susan Lewis; James K V Willson; John B Lowe; Georgia L Wiesner; Giovanni Parmigiani; Jill Barnholtz-Sloan; Dawn W Dawson; Victor E Velculescu; Kenneth W Kinzler; Nikolas Papadopoulos; Bert Vogelstein; Joseph Willis; Thomas A Gerken; Sanford D Markowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-17       Impact factor: 11.205
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