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Literature DB >> 12127544

N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus.

Edward Turos¹, Timothy E Long, Monika I Konaklieva, Cristina Coates, Jeung Yeop Shim, Sonja Dickey, Daniel V Lim, Andrew Cannons.

Abstract

In this report we describe a new family of N-thiolated beta-lactams that have antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). The compounds show unprecedented structure-activity features and an unusual mode of action for a beta-lactam antibiotic.

Entities: Chemical Species

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Year: 2002 PMID： 12127544 DOI： 10.1016/s0960-894x(02)00343-8

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

11 in total

1. N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus.

Authors: Kevin D Revell; Bart Heldreth; Timothy E Long; Seyoung Jang; Edward Turos
Journal: Bioorg Med Chem Date: 2006-12-20 Impact factor: 3.641

2. The impact of fatty acids on the antibacterial properties of N-thiolated β-lactams.

Authors: Katherine R Prosen; Ronan K Carroll; Whittney N Burda; Christina N Krute; Biplob Bhattacharya; My Lien Dao; Edward Turos; Lindsey N Shaw
Journal: Bioorg Med Chem Lett Date: 2011-07-19 Impact factor: 2.823

3. Studies on the antifungal properties of N-thiolated beta-lactams.

Authors: Marci O'Driscoll; Kerriann Greenhalgh; Ashley Young; Edward Turos; Sonja Dickey; Daniel V Lim
Journal: Bioorg Med Chem Date: 2008-06-25 Impact factor: 3.641

4. Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis.

Authors: Sampath C Abeylath; Edward Turos; Sonja Dickey; Daniel V Lim
Journal: Bioorg Med Chem Date: 2007-11-28 Impact factor: 3.641

5. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis.

Authors: Edward Turos; Kevin D Revell; Praveen Ramaraju; Danielle A Gergeres; Kerriann Greenhalgh; Ashley Young; Nalini Sathyanarayan; Sonja Dickey; Daniel Lim; Mamoun M Alhamadsheh; Kevin Reynolds
Journal: Bioorg Med Chem Date: 2008-05-17 Impact factor: 3.641

6. Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring.

Authors: Michael Frezza; Julio Garay; Di Chen; Cindy Cui; Edward Turos; Q Ping Dou
Journal: Int J Mol Med Date: 2008-06 Impact factor: 4.101

N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus.

1. N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus.

2. The impact of fatty acids on the antibacterial properties of N-thiolated β-lactams.

3. Studies on the antifungal properties of N-thiolated beta-lactams.

4. Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis.

5. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis.

6. Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring.

7. Anti-tumor activity of N-thiolated beta-lactam antibiotics.

8. Penicillin-bound polyacrylate nanoparticles: restoring the activity of beta-lactam antibiotics against MRSA.

9. Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols.

Review 10. Molecular Targets of β-Lactam-Based Antimicrobials: Beyond the Usual Suspects.