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Literature DB >> 18672374

Studies on the antifungal properties of N-thiolated beta-lactams.

Marci O'Driscoll¹, Kerriann Greenhalgh, Ashley Young, Edward Turos, Sonja Dickey, Daniel V Lim.

Abstract

N-thiolated beta-lactams had previously been shown to have antibacterial activity against a narrow selection of pathogenic bacteria including Staphylococcus aureus and Bacillus anthracis, as well as apoptotic-inducing activity in a variety of human cancer cell lines. We now have found that these lactams also possess antifungal activity against Candida and other fungi by exerting powerful cytostatic effects that disrupt the structural integrity of cytoplasmic membranes. The mode of action and structure-activity trends of these lactams as antifungals parallel that previously seen in our antibacterial studies.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2008 PMID： 18672374 PMCID： PMC2617728 DOI： 10.1016/j.bmc.2008.06.035

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

27 in total

Review 1. Transmission electron microscopy of yeast.

Authors: R Wright
Journal: Microsc Res Tech Date: 2000-12-15 Impact factor: 2.769

2. N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus.

Authors: Kevin D Revell; Bart Heldreth; Timothy E Long; Seyoung Jang; Edward Turos
Journal: Bioorg Med Chem Date: 2006-12-20 Impact factor: 3.641

3. N-Methylthio beta-lactam antibacterials: effects of the C3/C4 ring substituents on anti-MRSA activity.

Authors: Edward Turos; Cristina Coates; Jeung-Yeop Shim; Yang Wang; J Michelle Leslie; Timothy E Long; G Suresh Kumar Reddy; Alex Ortiz; Marci Culbreath; Sonja Dickey; Daniel V Lim; Eduardo Alonso; Javier Gonzalez
Journal: Bioorg Med Chem Date: 2005-09-26 Impact factor: 3.641

4. The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women.

Authors: J D Sobel; S E Ohmit; P Schuman; R S Klein; K Mayer; A Duerr; J A Vazquez; A Rampalo
Journal: J Infect Dis Date: 2001-01-15 Impact factor: 5.226

5. Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States.

Authors: M A Pfaller; S A Messer; R J Hollis; R N Jones; G V Doern; M E Brandt; R A Hajjeh
Journal: Diagn Microbiol Infect Dis Date: 1999-04 Impact factor: 2.803

6. Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells.

Authors: Deborah J Kuhn; Yang Wang; Vesna Minic; Cristina Coates; G Suresh Kumar Reddy; Kenyon G Daniel; Jeung-Yeop Shim; Di Chen; Kristin R Landis-Piwowar; Fred R Miller; Edward Turos; Q Ping Dou
Journal: Front Biosci Date: 2005-05-01

Review 7. Changing patterns and trends in systemic fungal infections.

Authors: Malcolm D Richardson
Journal: J Antimicrob Chemother Date: 2005-09 Impact factor: 5.790

Review 8. Importance of Candida species other than Candida albicans as opportunistic pathogens.

Authors: D C Coleman; M G Rinaldi; K A Haynes; J H Rex; R C Summerbell; E J Anaissie; A Li; D J Sullivan
Journal: Med Mycol Date: 1998 Impact factor: 4.076

9. N-Thiolated beta-lactam antibacterials: effects of the N-organothio substituent on anti-MRSA activity.

Authors: Bart Heldreth; Timothy E Long; Seyoung Jang; G Suresh Kumar Reddy; Edward Turos; Sonja Dickey; Daniel V Lim
Journal: Bioorg Med Chem Date: 2006-02-15 Impact factor: 3.641

10. N-thiolated beta-lactams: a new family of anti-Bacillus agents.

Authors: Edward Turos; Timothy E Long; Bart Heldreth; J Michelle Leslie; G Suresh Kumar Reddy; Yang Wang; Cristina Coates; Monika Konaklieva; Sonja Dickey; Daniel V Lim; Eduardo Alonso; Javier Gonzalez
Journal: Bioorg Med Chem Lett Date: 2006-02-13 Impact factor: 2.823

5 in total

Studies on the antifungal properties of N-thiolated beta-lactams.

Review 1. Transmission electron microscopy of yeast.

2. N-thiolated beta-lactams: Studies on the mode of action and identification of a primary cellular target in Staphylococcus aureus.

3. N-Methylthio beta-lactam antibacterials: effects of the C3/C4 ring substituents on anti-MRSA activity.

4. The evolution of Candida species and fluconazole susceptibility among oral and vaginal isolates recovered from human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women.

5. Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States.

6. Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells.

Review 7. Changing patterns and trends in systemic fungal infections.

Review 8. Importance of Candida species other than Candida albicans as opportunistic pathogens.

9. N-Thiolated beta-lactam antibacterials: effects of the N-organothio substituent on anti-MRSA activity.

10. N-thiolated beta-lactams: a new family of anti-Bacillus agents.

1. Proline-based phosphoramidite reagents for the reductive ligation of S-nitrosothiols.

2. Synthesis of some new mono- and bis-polycyclic aromatic spiro and bis-nonspiro-beta-lactams.

3. The potential role of the 5,6-dihydropyridin-2(1H)-one unit of piperlongumine on the anticancer activity.

Review 4. Drug repurposing strategies in the development of potential antifungal agents.

Review 5. Fungal Lactamases: Their Occurrence and Function.