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Literature DB >> 1212435

Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets.

Abstract

The distribution of fibrinogen, platelet factor 4 (heparin-neutralizing factor) and factor XIII amongst subcellular fractions of human platelets was determined. It was found that fibrinogen and platelet factor 4 peaked sharply in the region of the density gradient previously shown to be heavily enriched with alpha-granules. By contrast, factor XIII, fibrin-stabilizing factor, was found exclusively in the supernatant.

Entities: Gene Species

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Year: 1975 PMID： 1212435 DOI： 10.1111/j.1365-2141.1975.tb00831.x

Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998

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Cited

13 in total

1. Thrombin generation and secretion of platelet Factor 4 during blood clotting.

Authors: M A Shuman; S P Levine
Journal: J Clin Invest Date: 1978-04 Impact factor: 14.808

2. Subcellular localization of the heparin-neutralizing factor in blood platelets.

Authors: M Da Prada; M Jakábová; E F Lüscher; A Pletscher; J G Richards
Journal: J Physiol Date: 1976-05 Impact factor: 5.182

3. Structure of the rat platelet factor 4 gene: a marker for megakaryocyte differentiation.

Authors: T Doi; S M Greenberg; R D Rosenberg
Journal: Mol Cell Biol Date: 1987-02 Impact factor: 4.272

4. Defective alpha-granule production in megakaryocytes from gray platelet syndrome: ultrastructural studies of bone marrow cells and megakaryocytes growing in culture from blood precursors.

Authors: J Breton-Gorius; W Vainchenker; A Nurden; S Levy-Toledano; J Caen
Journal: Am J Pathol Date: 1981-01 Impact factor: 4.307

5. Optimal techniques for the immunocytochemical demonstration of beta-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets.

Authors: P E Stenberg; M A Shuman; S P Levine; D F Bainton
Journal: Histochem J Date: 1984-09

Distribution of fibrinogen, and platelet factors 4 and XIII in subcellular fractions of human platelets.

1. Thrombin generation and secretion of platelet Factor 4 during blood clotting.

2. Subcellular localization of the heparin-neutralizing factor in blood platelets.

3. Structure of the rat platelet factor 4 gene: a marker for megakaryocyte differentiation.

4. Defective alpha-granule production in megakaryocytes from gray platelet syndrome: ultrastructural studies of bone marrow cells and megakaryocytes growing in culture from blood precursors.

5. Optimal techniques for the immunocytochemical demonstration of beta-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets.

6. Subcellular localization and secretion of factor V from human platelets.

Review 7. Platelet activation in normo- and hyperlipoproteinemias.

8. Exposure of platelet fibrinogen receptors by ADP and epinephrine.

9. Biochemical studies of two patients with the gray platelet syndrome. Selective deficiency of platelet alpha granules.

10. High-molecular weight kininogen. A secreted platelet protein.