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Literature DB >> 950602

Subcellular localization of the heparin-neutralizing factor in blood platelets.

M Da Prada, M Jakábová, E F Lüscher, A Pletscher, J G Richards.

Abstract

1. The distribution of the heparin-neutralizing factor (platelet factor 4, PF4) in subcellular organelles of blood platelets of rabbits and man was investigated. 2. In both species the organelles storing 5-hydroxytryptamine (5-HT storage organelles) contained only trivial amounts of PF4. 3. In contrast, the content of PF4 was highest in the subcellular fractions rich in alpha-granules. 4. In conclusion, PF4 is probably localized in the alpha-granules and therefore the platelets contain at least two types of organelles (5-HT organelles and alpha-granules) capable of releasing their contents in response to the same stimuli, such as exposure to collagen, thrombin, etc.

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Year: 1976 PMID： 950602 PMCID： PMC1309371 DOI： 10.1113/jphysiol.1976.sp011380

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

22 in total

1. Identification and assay of serotonin in brain.

Authors: D F BOGDANSKI; A PLETSCHER; B B BRODIE; S UNDENFRIEND
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2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Platelet antiheparin activity: storage site and release mechanism.

Authors: P N Walsh; G Gagnatelli
Journal: Blood Date: 1974-08 Impact factor: 22.113

4. Storage of 5-hydroxytryptamine in human blood platelets.

Authors: M Da Prada; J P Tranzer; A Pletscher
Journal: Experientia Date: 1972-11-15

Review 5. Mechanisms of 5-hydroxytryptamine storage in subcellular organelles of blood platelets.

Authors: M Da Prada; A Pletscher
Journal: Adv Biochem Psychopharmacol Date: 1974

6. Storage of biogenic amines in blood platelets and adrenal medulla. Lack of evidence for direct involvement of glycosaminoglycans.

Authors: M Da Prada; K Von Berlepsch; A Pletscher
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1972 Impact factor: 3.000

7. Characterization of a chondroitin 4 -sulfate proteoglycan carrier for heparin neutralizing activity (platelet factor 4 ) released from human blood platelets.

Authors: A J Barber; R Käser-Glanzmann; M Jakábová; E F Lüscher
Journal: Biochim Biophys Acta Date: 1972-12-29

8. A mucopolysaccharide-protein complex with amine binding properties in rat thrombocytes.

Authors: C H Aborg; B Uvnäs
Journal: Acta Physiol Scand Date: 1971-04

9. The isolation and characterisation of a platelet-specific beta-globulin (beta-thromboglobulin) and the detection of antiurokinase and antiplasmin released from thrombin-aggregated washed human platelets.

Authors: S Moore; D S Pepper; J D Cash
Journal: Biochim Biophys Acta Date: 1975-02-27

10. The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation.

Authors: D C Mills; I A Robb; G C Roberts
Journal: J Physiol Date: 1968-04 Impact factor: 5.182

9 in total

1. Thrombin generation and secretion of platelet Factor 4 during blood clotting.

Authors: M A Shuman; S P Levine
Journal: J Clin Invest Date: 1978-04 Impact factor: 14.808

Review 2. Mechanism of platelet function with particular reference to the effects of drugs acting as inhibitors.

Authors: E F Lüscher
Journal: Agents Actions Date: 1978-04

Review 3. Platelet responses in health and disease.

Authors: M I Barnhart
Journal: Mol Cell Biochem Date: 1978-12-22 Impact factor: 3.396

4. Ultrastructural studies of the gray platelet syndrome.

Authors: J G White
Journal: Am J Pathol Date: 1979-05 Impact factor: 4.307

5. Defective alpha-granule production in megakaryocytes from gray platelet syndrome: ultrastructural studies of bone marrow cells and megakaryocytes growing in culture from blood precursors.

Authors: J Breton-Gorius; W Vainchenker; A Nurden; S Levy-Toledano; J Caen
Journal: Am J Pathol Date: 1981-01 Impact factor: 4.307

6. Optimal techniques for the immunocytochemical demonstration of beta-thromboglobulin, platelet factor 4, and fibrinogen in the alpha granules of unstimulated platelets.

Authors: P E Stenberg; M A Shuman; S P Levine; D F Bainton
Journal: Histochem J Date: 1984-09