Literature DB >> 12123595

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

Orion D Weiner1.   

Abstract

P-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules.

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Year:  2002        PMID： 12123595      PMCID： PMC2819105          DOI： 10.1016/s0960-9822(02)00917-x

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


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