Literature DB >> 12123009

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

M Isabel García-Moreno1, Paula Díaz-Pérez, Carmen Ortiz Mellet, José M García Fernández.   

Abstract

Bicyclic azasugar glycomimetics related to castanospermine and trehazolin have been prepared from sugar carbodiimides via aminooxazoline intermediates; preliminary enzyme inhibition tests showed a marked dependence of the selectivity and potency towards alpha and beta-glucosidases upon the nature of the exocyclic substituent.

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Year:  2002        PMID： 12123009     DOI： 10.1039/b200162d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase.

Authors:  Alen Sevšek; Javier Sastre Toraño; Linda Quarles van Ufford; Ed E Moret; Roland J Pieters; Nathaniel I Martin
Journal:  Medchemcomm       Date:  2017-10-10       Impact factor: 3.597

2.  Iminosugars Spiro-Linked with Morpholine-Fused 1,2,3-Triazole: Synthesis, Conformational Analysis, Glycosidase Inhibitory Activity, Antifungal Assay, and Docking Studies.

Authors:  Shrawan R Chavan; Kishor S Gavale; Ayesha Khan; Rakesh Joshi; Navanath Kumbhar; Debamitra Chakravarty; Dilip D Dhavale
Journal:  ACS Omega       Date:  2017-10-26

3.  Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

Authors:  Teresa Mena-Barragán; M Isabel García-Moreno; Alen Sevšek; Tetsuya Okazaki; Eiji Nanba; Katsumi Higaki; Nathaniel I Martin; Roland J Pieters; José M García Fernández; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2018-04-17       Impact factor: 4.411

4.  Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids.

Authors:  Elena M Sánchez-Fernández; M Isabel García-Moreno; Raquel García-Hernández; José M Padrón; José M García Fernández; Francisco Gamarro; Carmen Ortiz Mellet
Journal:  Molecules       Date:  2019-08-08       Impact factor: 4.411
  4 in total

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