Literature DB >> 12120377

Polyclonal antibody-catalysed hydrolysis of a beta-lactam.

Elizabeth L Ostler1, Marina Resmini, Guillaume Boucher, Nickolas Romanov, Keith Brocklehurst, Gerard Gallacher.   

Abstract

We report the first example of antibody-catalysed hydrolysis of a beta-lactam where the antibodies were generated by a simple transition-state analogue; in this example the antibodies are polyclonal.

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Year:  2002        PMID： 12120377     DOI： 10.1039/b110135h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.

Authors:  Sheraz Gul; Sanjiv Sonkaria; Surapong Pinitglang; José Florez-Alvarez; Syeed Hussain; Emrys W Thomas; Elizabeth L Ostler; Gerard Gallacher; Marina Resmini; Keith Brocklehurst
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

2.  Evidence that the mechanism of antibody-catalysed hydrolysis of arylcarbamates can be determined by the structure of the immunogen used to elicit the catalytic antibody.

Authors:  Guillaume Boucher; Bilal Said; Elizabeth L Ostler; Marina Resmini; Keith Brocklehurst; Gerard Gallacher
Journal:  Biochem J       Date:  2007-02-01       Impact factor: 3.857
  2 in total

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