Literature DB >> 12116870

Modified berberine and protoberberines from Enantia chlorantha as potential inhibitors of Trypanosoma brucei.

B Nyasse1, E Nkwengoua, B Sondengam, C Denier, M Willson.   

Abstract

Phytochemical study of the stem bark of Enantia chlorantha resulted in the isolation of two protoberberines 1 and 2. These alkaloids as well as commercially available berberine were modified chemically and tested in vitro against Typanosoma brucei proliferation as well as on three targeted glycolytic enzymes. The inhibitory activities observed were in the range of 20 microM (ED50 values).

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Year:  2002        PMID： 12116870

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  3 in total

Review 1.  A Review on Traditionally Used African Medicinal Plant Annickia chlorantha, Its Phytochemistry, and Anticancer Potential.

Authors:  Paromita Sarbadhikary; Blassan P George
Journal:  Plants (Basel)       Date:  2022-09-02

2.  Mosquitocidal Activity of the Methanolic Extract of Annickiachlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio.

Authors:  Tharwat A Selim; Ibrahim E Abd-El Rahman; Hesham A Mahran; Hamza A M Adam; Vincent Imieje; Ahmed A Zaki; Mansour A E Bashar; Hossam Hwihy; Abdelaaty Hamed; Ahmed A Elhenawy; Eman S Abou-Amra; Samia E El-Didamony; Ahmed I Hasaballah
Journal:  Insects       Date:  2022-07-27       Impact factor: 3.139

Review 3.  Update on Medicinal Plants with Potency on Mycobacterium ulcerans.

Authors:  Patrick Valere Tsouh Fokou; Alexander Kwadwo Nyarko; Regina Appiah-Opong; Lauve Rachel Tchokouaha Yamthe; Mark Ofosuhene; Fabrice Fekam Boyom
Journal:  Biomed Res Int       Date:  2015-12-08       Impact factor: 3.411
  3 in total

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