Literature DB >> 12115981

Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity.

Aphrodite Vasilaki1, Malcolm J Jackson, Anne McArdle.   

Abstract

The aim of this study was to investigate the production of HSP70 in gastrocnemius muscles from adult (6-month-old) and aged (28-month-old) rats following contractile activity. At 24 h following a period of repeated isometric contractions, muscles from adult rats contained significantly elevated levels of HSP70 compared with nonexercised muscle. This was not evident in muscles from aged rats. This attenuated response may play a major role in development of the age-related functional deficit that occurs in skeletal muscle. Copyright 2002 Wiley Periodicals, Inc.

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Year:  2002        PMID： 12115981     DOI： 10.1002/mus.10094

Source DB:  PubMed          Journal:  Muscle Nerve        ISSN： 0148-639X            Impact factor:   3.217


  21 in total

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