BACKGROUND: Neurobiologic abnormalities in dorsolateral prefrontal cortex (DLPFC) are believed to be involved in the pathophysiology of major depressive disorder (MDD). Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined the DLPFC in pediatric patients with MDD. METHODS: In this study, choline compounds (Cho), N-acetylaspartate (NAA), and creatine/phosphocreatine (Cr) were measured in left and right DLPFC using a multislice proton magnetic resonance spectroscopic imaging sequence with validated phantom replacement methodology in 11 treatment-naïve MDD patients, 10-16 years of age, and 11 case-matched healthy control subjects. RESULTS: A significant increase in Cho was observed in left but not right DLPFC in MDD patients versus control subjects (32.5% higher). No significant differences in NAA or Cr were observed between case-control pairs. CONCLUSIONS: These results provide new evidence of localized functional neurochemical marker alterations in left DLPFC in pediatric MDD. Our results must be considered preliminary, however, given the small sample size.
BACKGROUND: Neurobiologic abnormalities in dorsolateral prefrontal cortex (DLPFC) are believed to be involved in the pathophysiology of major depressive disorder (MDD). Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined the DLPFC in pediatric patients with MDD. METHODS: In this study, choline compounds (Cho), N-acetylaspartate (NAA), and creatine/phosphocreatine (Cr) were measured in left and right DLPFC using a multislice proton magnetic resonance spectroscopic imaging sequence with validated phantom replacement methodology in 11 treatment-naïve MDDpatients, 10-16 years of age, and 11 case-matched healthy control subjects. RESULTS: A significant increase in Cho was observed in left but not right DLPFC in MDDpatients versus control subjects (32.5% higher). No significant differences in NAA or Cr were observed between case-control pairs. CONCLUSIONS: These results provide new evidence of localized functional neurochemical marker alterations in left DLPFC in pediatric MDD. Our results must be considered preliminary, however, given the small sample size.
Authors: Robert K McNamara; Jeffrey R Strawn; Max J Tallman; Jeffrey A Welge; L Rodrigo Patino; Thomas J Blom; Melissa P DelBello Journal: J Child Adolesc Psychopharmacol Date: 2020-03-11 Impact factor: 2.576
Authors: Rene Luis Olvera; Sheila C Caetano; Jeffrey A Stanley; Hua-Hsuan Chen; Mark Nicoletti; John P Hatch; Manoela Fonseca; Steven R Pliszka; Jair C Soares Journal: Psychiatry Res Date: 2010-11-30 Impact factor: 3.222
Authors: Ashley Acheson; S Andrea Wijtenburg; Laura M Rowland; Bethany C Bray; Frank Gaston; Charles W Mathias; Peter T Fox; William R Lovallo; Susan N Wright; L Elliot Hong; Stephen McGuire; Peter Kochunov; Donald M Dougherty Journal: Hum Brain Mapp Date: 2014-07-21 Impact factor: 5.038
Authors: Erin Fallucca; Frank P MacMaster; Joseph Haddad; Phillip Easter; Rachel Dick; Geoffrey May; Jeffrey A Stanley; Carrie Rix; David R Rosenberg Journal: Arch Gen Psychiatry Date: 2011-05
Authors: Min Soo Byun; Jung-Seok Choi; So Young Yoo; Do-Hyung Kang; Chi-Hoon Choi; Dong Pyo Jang; Wi Hoon Jung; Myung Hun Jung; Joon Hwan Jang; Jong-Min Lee; Jun Soo Kwon Journal: Psychiatry Investig Date: 2009-11-21 Impact factor: 2.505
Authors: Frank P MacMaster; Gregory J Moore; Aileen Russell; Yousha Mirza; S Preeya Taormina; Christian Buhagiar; David R Rosenberg Journal: Psychiatry Res Date: 2008-08-13 Impact factor: 3.222
Authors: Xian-Feng Shi; Lauren N Forrest; M Danielle Kuykendall; Andrew P Prescot; Young-Hoon Sung; Rebekah S Huber; Tracy L Hellem; Eun-Kee Jeong; Perry F Renshaw; Douglas G Kondo Journal: J Affect Disord Date: 2014-06-02 Impact factor: 4.839