Literature DB >> 12113809

Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.

Takeshi Honda1, Takeshi Masuda, Shuku Yoshida, Masami Arai, Yoshiyuki Kobayashi, Makoto Yamashita.   

Abstract

Substitution of 7-OH by small hydrophobic groups on zanamivir resulted in the retaining of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. These compounds were prepared by treatment of the corresponding 7-substituted sialic acids derived from 4-modified N-acetyl-D-mannosamine (ManNAc) using enzyme-catalyzed aldol condensation.

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Year:  2002        PMID： 12113809     DOI： 10.1016/s0960-894x(02)00328-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies.

Authors:  Zahra Khedri; Yanhong Li; Saddam Muthana; Musleh M Muthana; Ching-Wen Hsiao; Hai Yu; Xi Chen
Journal:  Carbohydr Res       Date:  2014-03-06       Impact factor: 2.104

2.  Consensus QSAR model for identifying novel H5N1 inhibitors.

Authors:  Nitin Sharma; Chun Wei Yap
Journal:  Mol Divers       Date:  2012-07-21       Impact factor: 2.943

3.  CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity.

Authors:  Makoto Yamashita; Takanori Tomozawa; Masayo Kakuta; Akane Tokumitsu; Hatsumi Nasu; Shuku Kubo
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191

4.  Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses.

Authors:  Maki Kiso; Shuku Kubo; Makoto Ozawa; Quynh Mai Le; Chairul A Nidom; Makoto Yamashita; Yoshihiro Kawaoka
Journal:  PLoS Pathog       Date:  2010-02-26       Impact factor: 6.823

5.  A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Authors:  Masahiko Hayakawa; Narihiro Toda; Nancy Carrillo; Natalie J Thornburg; James E Crowe; Carlos F Barbas
Journal:  Chembiochem       Date:  2012-09-10       Impact factor: 3.164

6.  Solution phase conformation and proteolytic stability of amide-linked neuraminic acid analogues.

Authors:  Jonel P Saludes; Travis Q Gregar; I Abrrey Monreal; Brandan M Cook; Lieza M Danan-Leon; Jacquelyn Gervay-Hague
Journal:  Biopolymers       Date:  2013-10       Impact factor: 2.505

7.  CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract.

Authors:  Kumiko Koyama; Makoto Takahashi; Masataka Oitate; Naoko Nakai; Hideo Takakusa; Shin-ichi Miura; Osamu Okazaki
Journal:  Antimicrob Agents Chemother       Date:  2009-08-17       Impact factor: 5.191

8.  Synthesis and Biological Evaluation of Non-Hydrolizable 1,2,3-Triazole Linked Sialic Acid Derivatives as Neuraminidase Inhibitors.

Authors:  Michel Weïwer; Chi-Chang Chen; Melissa M Kemp; Robert J Linhardt
Journal:  European J Org Chem       Date:  2009-06

9.  Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors.

Authors:  An Xiao; Yanhong Li; Xixuan Li; Abhishek Santra; Hai Yu; Wanqing Li; Xi Chen
Journal:  ACS Catal       Date:  2017-11-21       Impact factor: 13.084

10.  Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities.

Authors:  Nongluk Sriwilaijaroen; Prapon Wilairat; Hiroaki Hiramatsu; Tadanobu Takahashi; Takashi Suzuki; Morihiro Ito; Yasuhiko Ito; Masato Tashiro; Yasuo Suzuki
Journal:  Virol J       Date:  2009-08-13       Impact factor: 4.099
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