| Literature DB >> 12112299 |
E Mongelli1, A B Pomilio, J Bustamante Sánchez, F M Guerra, G Martínez Massanet.
Abstract
Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL). Copyright 2002 John Wiley & Sons, Ltd.Entities:
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Year: 2002 PMID： 12112299 DOI： 10.1002/ptr.955
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878