| Literature DB >> 12107656 |
J A Kanis1, A Oden, O Johnell, F Caulin, H Bone, J-M Alexandre, E Abadie, F Lekkerkerker.
Abstract
The advent of effective agents for the treatment of osteoporosis has led to the view that placebo-controlled trials to test new agents for efficacy are no longer appropriate since proven treatments are available. In this review we argue that, if new agents are to be developed, there is still a place for the placebo-controlled trial. A move to studies of equivalence or non-inferiority raises more problems than it resolves.Entities:
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Year: 2002 PMID： 12107656 DOI： 10.1007/s001980200052
Source DB: PubMed Journal: Osteoporos Int ISSN： 0937-941X Impact factor: 4.507