OBJECTIVE: The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate. METHODS: Three studies of elderly depressed patients provided data on antidepressant treatment response in 323 subjects, treated in protocols using either nortriptyline or paroxetine. We grouped the subjects by current age: 'young-old' (59-69, N=163), 'middle-old' (70-75, N=80), and 'older-old' (76-99, N=80). We employed mixed-effect random regression analyses to examine Hamilton Rating Scale for Depression scores over 12 weeks of acute treatment. RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age.
OBJECTIVE: The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate. METHODS: Three studies of elderly depressedpatients provided data on antidepressant treatment response in 323 subjects, treated in protocols using either nortriptyline or paroxetine. We grouped the subjects by current age: 'young-old' (59-69, N=163), 'middle-old' (70-75, N=80), and 'older-old' (76-99, N=80). We employed mixed-effect random regression analyses to examine Hamilton Rating Scale for Depression scores over 12 weeks of acute treatment. RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age.
Authors: Carmen Andreescu; Benoit H Mulsant; Patricia R Houck; Ellen M Whyte; Sati Mazumdar; Alexandre Y Dombrovski; Bruce G Pollock; Charles F Reynolds Journal: Am J Psychiatry Date: 2008-05-01 Impact factor: 18.112
Authors: Ellen M Whyte; Mary Amanda Dew; Ariel Gildengers; Eric J Lenze; Ashok Bharucha; Benoit H Mulsant; Charles F Reynolds Journal: Drugs Aging Date: 2004 Impact factor: 3.923
Authors: Jordan F Karp; Ellen M Whyte; Eric J Lenze; Mary A Dew; Amy Begley; Mark D Miller; Charles F Reynolds Journal: J Clin Psychiatry Date: 2008-03 Impact factor: 4.384
Authors: Christian Knöchel; Gilberto Alves; Benedikt Friedrichs; Barbara Schneider; Anna Schmidt-Rechau; Sofia Wenzler; Angelina Schneider; David Prvulovic; André F Carvalho; Viola Oertel-Knöchel Journal: Curr Neuropharmacol Date: 2015 Impact factor: 7.363