PURPOSE: Depressive disorders are common among the very old, but insufficiently studied. The present study aims to identify risk factors for depressive disorders in very old age. METHODS: The present study is based on the GERDA project, a population-based cohort study of people aged ≥85 years (n = 567), with 5 years between baseline and follow-up. Factors associated with the development of depressive disorders according to DSM-IV criteria at follow-up were analysed by means of a multivariate logistic regression. RESULTS: At baseline, depressive disorders were present in 32.3 % of the participants. At follow-up, 69 % of those with baseline depressive disorders had died. Of the 49 survivors, 38 still had depressive disorders. Of the participants without depressive disorders at baseline, 25.5 % had developed depressive disorders at follow-up. Baseline factors independently associated with new cases of depressive disorders after 5 years were hypertension, a history of stroke and 15-item Geriatric Depression Scale score at baseline. CONCLUSIONS: The present study supports the earlier findings that depressive disorders among the very old are common, chronic and malignant. Mild depressive symptoms as indicated by GDS-15 score and history of stroke or hypertension seem to be important risk factors for incident depressive disorders in very old age.
PURPOSE:Depressive disorders are common among the very old, but insufficiently studied. The present study aims to identify risk factors for depressive disorders in very old age. METHODS: The present study is based on the GERDA project, a population-based cohort study of people aged ≥85 years (n = 567), with 5 years between baseline and follow-up. Factors associated with the development of depressive disorders according to DSM-IV criteria at follow-up were analysed by means of a multivariate logistic regression. RESULTS: At baseline, depressive disorders were present in 32.3 % of the participants. At follow-up, 69 % of those with baseline depressive disorders had died. Of the 49 survivors, 38 still had depressive disorders. Of the participants without depressive disorders at baseline, 25.5 % had developed depressive disorders at follow-up. Baseline factors independently associated with new cases of depressive disorders after 5 years were hypertension, a history of stroke and 15-item Geriatric Depression Scale score at baseline. CONCLUSIONS: The present study supports the earlier findings that depressive disorders among the very old are common, chronic and malignant. Mild depressive symptoms as indicated by GDS-15 score and history of stroke or hypertension seem to be important risk factors for incident depressive disorders in very old age.
Authors: D J Vinkers; M L Stek; R C van der Mast; A J M de Craen; S Le Cessie; J Jolles; R G J Westendorp; J Gussekloo Journal: Neurology Date: 2005-07-12 Impact factor: 9.910
Authors: David J Vinkers; Max L Stek; Jacobijn Gussekloo; Roos C Van Der Mast; Rudi G J Westendorp Journal: Int J Geriatr Psychiatry Date: 2004-09 Impact factor: 3.485
Authors: K R Krishnan; W M McDonald; P M Doraiswamy; L A Tupler; M Husain; O B Boyko; G S Figiel; E H Ellinwood Journal: Eur Arch Psychiatry Clin Neurosci Date: 1993 Impact factor: 5.270
Authors: Gerda M Van der Weele; Jacobijn Gussekloo; Margot W M De Waal; Anton J M De Craen; Roos C Van der Mast Journal: Int J Geriatr Psychiatry Date: 2009-06 Impact factor: 3.485
Authors: R C van der Mast; D J Vinkers; M L Stek; M C Bek; R G J Westendorp; J Gussekloo; A J M de Craen Journal: Int J Geriatr Psychiatry Date: 2008-03 Impact factor: 3.485