Modulations in corticomotor excitability during passive upper-limb movement: is there a cortical influence?

Modulations in the excitability of corticomotor pathways to forearm musculature have previously been demonstrated during passive wrist movement [Brain Res. 900 (2001) 282]. Investigations were conducted to determine the level of the neuroaxis at which these modulations arise, and to establish the influence of proprioceptive task constraints on pathway excitability. Forearm motor evoked potentials (MEPs) in response to transcranial magnetic stimulation (TMS) were examined during passive wrist movement while subjects maintained a low-level muscle activation, thus stabilising the excitability of the motoneuron pool. Modulations in response amplitude during movement were evident in both forearm flexor and extensor muscles. The pattern of modulation generally mirrored that seen in quiescent musculature during movement, with responses potentiated during the phases where the muscle was in a shortened position. Variations in MEP amplitude were not detected while the wrist was constrained statically at various joint angles. This suggests a dynamic influence of movement, most likely mediated by spindle receptors, arising at a supraspinal level. We also investigated the influence of a kinesthetic tracking task on corticomotor excitability during passive movement of the wrist joint. MEPs were recorded from the target driven limb while the contralateral limb was stationary, while the contralateral limb actively tracked the movements of the target limb, and while the contralateral limb moved actively in time with a metronome. The results revealed no differences in MEP characteristics in the driven limb between the three conditions. Placing the movement elicited afferent information in an active movement context does not appear to enhance the modulations in cortical excitability.