AIMS: To determine whether bolus doses of methylprednisolone affect the steady-state trough concentrations of sirolimus. METHODS:Fourteen renal transplant recipients receivedconcentration-controlled sirolimus therapy in combination with azathioprine and steroids (n=8) or mycophenolate mofetil and steroids (n=6). Bolus doses of methylprednisolone (mean total dose over 1-5 days, 1694 mg; range, 500-3000 mg) were given for the treatment of acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3-52.5 mg) was the same before and during methylprednisolone therapy. RESULTS:Mean sirolimus whole blood trough concentrations before and after treatment with methylprednisolone were 28.8 ng ml-1 (range, 13.9-45.3 ng ml-1), and 28.5 ng ml-1 (range, 13.0-47.9 ng ml-1), respectively (P=0.85; 95% confidence interval on the difference -3.3, 4.0 ng ml-1). CONCLUSIONS: Bolus methylprednisolone treatment does not affect steady-state sirolimus trough concentrations.
RCT Entities:
AIMS: To determine whether bolus doses of methylprednisolone affect the steady-state trough concentrations of sirolimus. METHODS: Fourteen renal transplant recipients received concentration-controlled sirolimus therapy in combination with azathioprine and steroids (n=8) or mycophenolate mofetil and steroids (n=6). Bolus doses of methylprednisolone (mean total dose over 1-5 days, 1694 mg; range, 500-3000 mg) were given for the treatment of acute rejection. For each patient, the sirolimus dose (mean, 24.1 mg; range, 3.3-52.5 mg) was the same before and during methylprednisolone therapy. RESULTS: Mean sirolimus whole blood trough concentrations before and after treatment with methylprednisolone were 28.8 ng ml-1 (range, 13.9-45.3 ng ml-1), and 28.5 ng ml-1 (range, 13.0-47.9 ng ml-1), respectively (P=0.85; 95% confidence interval on the difference -3.3, 4.0 ng ml-1). CONCLUSIONS: Bolus methylprednisolone treatment does not affect steady-state sirolimus trough concentrations.
Authors: C G Groth; L Bäckman; J M Morales; R Calne; H Kreis; P Lang; J L Touraine; K Claesson; J M Campistol; D Durand; L Wramner; C Brattström; B Charpentier Journal: Transplantation Date: 1999-04-15 Impact factor: 4.939
Authors: L Pichard; I Fabre; G Fabre; J Domergue; B Saint Aubert; G Mourad; P Maurel Journal: Drug Metab Dispos Date: 1990 Sep-Oct Impact factor: 3.922
Authors: Wai-Hang Leung; Joel Gay; Unja Martin; Tracy E Garrett; Holly M Horton; Michael T Certo; Bruce R Blazar; Richard A Morgan; Philip D Gregory; Jordan Jarjour; Alexander Astrakhan Journal: JCI Insight Date: 2019-04-30