| Literature DB >> 12098227 |
K R Gee1, Z-L Zhou, D Ton-That, S L Sensi, J H Weiss.
Abstract
New fluorescent indicators with nanomolar to micromolar affinities for Zn(2+) have been synthesized in wavelengths from UV to the far red. The UV light-excited indicators are ratiometric. The visible wavelength indicators are non-ratiometric and exhibit large and pH-independent fluorescence increases with increasing zinc concentrations, with little to no sensitivity to physiologically relevant Ca(2+) concentrations. Experiments in neuronal and non-neuronal cell cultures show the new indicators to retain their sensitivity to and selectivity for zinc after conversion to cell-permeable forms. (c) 2002 Elsevier Science Ltd. All rights reserved.Entities:
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Year: 2002 PMID： 12098227 DOI： 10.1016/S0143-4160(02)00053-2
Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817