Literature DB >> 1209792

Concentration of antibiotics in renal interstitial fluid: an experimental model.

H U Eickenberg, N G Waterman, L Scharfenberger.   

Abstract

In a new canine experimental model the time concentration relationship of cephalothin in serum, urine, soft tissue interstitial fluid (STIF) and renal interstitial fluid (RIF) were compared simultaneously. Antibiotic concentration in RIF was less than urinary levels but exceeded the serum concentration. Urinary antibiotic concentration does not necessarily reflect concentration in the renal interstitium. This model helps to understand the basic pharmacokinetics of antibiotics in the renal interstitium where pyelonephritis occurs.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1209792     DOI： 10.1007/bf00261952

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  12 in total

1.  SOME FUNCTIONAL, PATHOLOGIC, BACTERIOLOGIC, AND CHEMOTHERAPEUTIC CHARACTERISTICS OF UNILATERAL PYELONEPHRITIS IN MAN. I. FUNCTIONAL AND PATHOLOGIC CHARACTERISTICS.

Authors:  T A STAMEY; A PFAU
Journal:  Invest Urol       Date:  1963-09

2.  THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS.

Authors:  T A STAMEY; D E GOVAN; J M PALMER
Journal:  Medicine (Baltimore)       Date:  1965-01       Impact factor: 1.889

3.  TREATMENT OF PYELONEPHRITIS: BACTERIAL, DRUG AND HOST FACTORS IN SUCCESS OR FAILURE AMONG 252 PATIENTS.

Authors:  W R MCCABE; G G JACKSON
Journal:  N Engl J Med       Date:  1965-05-20       Impact factor: 91.245

4.  Concentration of antibacterial agents in interstitial tissue fluid.

Authors:  G D Chisholm; P M Waterworth; J S Calnan; L P Garrod
Journal:  Br Med J       Date:  1973-03-10

5.  Interstitial fluid and serum antibiotic concentrations.

Authors:  N G Waterman; L B Kastan
Journal:  Arch Surg       Date:  1972-08

6.  Implanted tissue cages--a study in rabbits.

Authors:  J S Calnan; P M Ford; P J Holt; J J Pflug
Journal:  Br J Plast Surg       Date:  1972-04

Review 7.  Interstitial fluid pressure.

Authors:  A C Guyton; H J Granger; A E Taylor
Journal:  Physiol Rev       Date:  1971-07       Impact factor: 37.312

8.  Rapid microassay for circulating nephrotoxic antibiotics.

Authors:  L D Sabath; J I Casey; P A Ruch; L L Stumpf; M Finland
Journal:  Antimicrob Agents Chemother (Bethesda)       Date:  1970

9.  The localisation of cephaloridine and nitrofurantoin in the kidney.

Authors:  G A Currie; P J Little; S J McDonald
Journal:  Nephron       Date:  1966       Impact factor: 2.847

10.  Distribution of some newer antibiotics within the kidney interstitium: a therapeutic consideration in pyelonephritis.

Authors:  A T Cockett; R S Moore; A P Roberts
Journal:  Invest Urol       Date:  1967-11
View more
  4 in total

1.  Concentration relationships of cefaclor in serum, interstitial fluid, bile, and urine of dogs.

Authors:  N G Waterman; L F Scharfenberger
Journal:  Antimicrob Agents Chemother       Date:  1978-10       Impact factor: 5.191

2.  Concentration of cefamandole in serum interstitial fluid, bile, and urine.

Authors:  N G Waterman; H U Eickenberg; L Scharfenberger
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

3.  Rosamicin--a new drug for the treatment of bacterial prostatitis.

Authors:  A Baumueller; U Hoyme; P O Madsen
Journal:  Antimicrob Agents Chemother       Date:  1977-08       Impact factor: 5.191

4.  Measurements of antimicrobial drug concentrations in renal interstitial fluid using the diffusion chamber technique.

Authors:  A Georgopoulos; E Schütze; G Laber
Journal:  Infection       Date:  1980       Impact factor: 3.553
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.