OBJECTIVE: To analyze an unusual nonrobertsonian translocation t(6;11) found in an infertile, oligoazoospermic, but otherwise apparently healthy man. DESIGN: Case report with review of the scientific literature. SETTING: Academic research environment. PATIENT(S): Infertile, oligoazoospermic, but otherwise apparently healthy man. INTERVENTION(S): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by standard GBG, RBG, and CBG banding procedures. MAIN OUTCOME MEASURE(S): Sperm count, morphology, and GBG, RBG, and CBG banding. RESULT(S): A karyogram revealed a nonrobertsonian balanced translocation t(6;11) with breakpoints at 6q15 and 11p15, as shown by R-, G-, and C-banding. CONCLUSION(S): Physical contact of unpaired autosomal material with sex chromosomes, which leads to spermatogenic arrest, may be one of the factors that accounts for infertility in men with autosomal aberrations.
OBJECTIVE: To analyze an unusual nonrobertsonian translocation t(6;11) found in an infertile, oligoazoospermic, but otherwise apparently healthy man. DESIGN: Case report with review of the scientific literature. SETTING: Academic research environment. PATIENT(S): Infertile, oligoazoospermic, but otherwise apparently healthy man. INTERVENTION(S): Peripheral blood lymphocytes were obtained for karyotyping, and metaphases were studied by standard GBG, RBG, and CBG banding procedures. MAIN OUTCOME MEASURE(S): Sperm count, morphology, and GBG, RBG, and CBG banding. RESULT(S): A karyogram revealed a nonrobertsonian balanced translocation t(6;11) with breakpoints at 6q15 and 11p15, as shown by R-, G-, and C-banding. CONCLUSION(S): Physical contact of unpaired autosomal material with sex chromosomes, which leads to spermatogenic arrest, may be one of the factors that accounts for infertility in men with autosomal aberrations.