| Literature DB >> 12095319 |
Michael J Zacuto1, Steven J O'Malley, James L Leighton.
Abstract
Polyketide fragments may be rapidly and efficiently assembled in the tandem intramolecular silylformylation-crotylsilylation of alkenes and alkynes. The reactions establish up to three new stereocenters with good-to-excellent diastereoselectivity, and the use of the reaction in an iterative sense is demonstrated. In addition, a new dihydrosilane alcoholysis reaction has been developed, leading to a highly efficient sequence.Entities:
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Year: 2002 PMID： 12095319 DOI： 10.1021/ja026511y
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419