| Literature DB >> 12093010 |
Alan G Baxter1, Philip D Hodgkin.
Abstract
Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental observations and theoretical concerns that have helped to forge the most influential variants of the theory. We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future.Mesh：
Substances：
Year: 2002 PMID： 12093010 DOI： 10.1038/nri823
Source DB: PubMed Journal: Nat Rev Immunol ISSN： 1474-1733 Impact factor: 53.106