Literature DB >> 12090706

Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16.

Young-Myoung Chun1, Sung-Kyun Moon, Haa-Yung Lee, Paul Webster, Derald E Brackmann, Johng S Rhim, David J Lim.   

Abstract

A human middle ear epithelial cell line (HMEEC-1) was established using human papillomavirus E6/E7 genes. HMEEC-1 has remained morphologically and phenotypically stable, even after 50 passages. The cells are anchorage-dependent and nontumorigenic when injected into nude mice. This cell line thus provides a new tool for the study of normal cell biology and the pathological processes associated with the epithelial cells of the middle ear in otitis media. HMEEC-1 will also be useful in the search for new drugs and biological agents for the treatment of otitis media.

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Year:  2002        PMID： 12090706     DOI： 10.1177/000348940211100606

Source DB:  PubMed          Journal:  Ann Otol Rhinol Laryngol        ISSN： 0003-4894            Impact factor:   1.547


  39 in total

1.  Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria.

Authors:  Xia Chen; Susan L Thibeault
Journal:  Tissue Eng Part C Methods       Date:  2009-06       Impact factor: 3.056

2.  MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.

Authors:  Un-Hwan Ha; Jae Hyang Lim; Hyun-Joong Kim; Weihui Wu; Shouguang Jin; Haidong Xu; Jian-Dong Li
Journal:  J Biol Chem       Date:  2008-09-09       Impact factor: 5.157

3.  Differential response of gel-forming mucins to pathogenic middle ear bacteria.

Authors:  Joseph E Kerschner; Wenzhou Hong; Pawjai Khampang; Nikki Johnston
Journal:  Int J Pediatr Otorhinolaryngol       Date:  2014-06-06       Impact factor: 1.675

4.  Alteration of payload in extracellular vesicles by crosstalk with mesenchymal stem cells from different origin.

Authors:  Dong Jun Park; Jeong-Eun Park; Tae Hoon Kong; Young Joon Seo
Journal:  J Nanobiotechnology       Date:  2021-05-20       Impact factor: 10.435

5.  Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.

Authors:  Stéphanie Val; Anna Krueger; Marian Poley; Ariella Cohen; Kristy Brown; Aswini Panigrahi; Diego Preciado
Journal:  FASEB J       Date:  2018-01-05       Impact factor: 5.191

6.  Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.

Authors:  Jiyun Lee; Kensei Komatsu; Byung Cheol Lee; Jae Hyang Lim; Hirofumi Jono; Haidong Xu; Hirofumi Kai; Z John Zhang; Chen Yan; Jian-Dong Li
Journal:  J Biol Chem       Date:  2012-05-18       Impact factor: 5.157

7.  The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits.

Authors:  Timothy M VanWagoner; John M Atack; Kevin L Nelson; Hannah K Smith; Kate L Fox; Michael P Jennings; Terrence L Stull; Arnold L Smith
Journal:  Microb Pathog       Date:  2015-12-21       Impact factor: 3.738

8.  Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.

Authors:  Jae Hyang Lim; Hyun-Jung Kim; Kensei Komatsu; Unhwan Ha; Yuxian Huang; Hirofumi Jono; Soo-Mi Kweon; Jiyun Lee; Xiangbin Xu; Gen-Sheng Zhang; Huahao Shen; Hirofumi Kai; Wenhong Zhang; Haidong Xu; Jian-Dong Li
Journal:  Am J Transl Res       Date:  2009-05-08       Impact factor: 4.060

9.  Influenza-induced inflammation drives pneumococcal otitis media.

Authors:  Kirsty R Short; Patrick C Reading; Lorena E Brown; John Pedersen; Brad Gilbertson; Emma R Job; Kathryn M Edenborough; Marrit N Habets; Aldert Zomer; Peter W M Hermans; Dimitri A Diavatopoulos; Odilia L Wijburg
Journal:  Infect Immun       Date:  2013-01-14       Impact factor: 3.441

10.  Biofilm growth increases phosphorylcholine content and decreases potency of nontypeable Haemophilus influenzae endotoxins.

Authors:  Shayla West-Barnette; Andrea Rockel; W Edward Swords
Journal:  Infect Immun       Date:  2006-03       Impact factor: 3.441
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