Literature DB >> 12089469

Theoretical approaches to holistic biological features: Pattern formation, neural networks and the brain-mind relation.

Alfred Gierer1.   

Abstract

The topic of this article is the relation between bottom-up and top-down, reductionist and holistic approaches to the solution of basic biological problems. While there is no doubt that the laws of physics apply to all events in space and time, including the domains of life, understanding biology depends not only on elucidating the role of the molecules involved, but, to an increasing extent, on systems theoretical approaches in diverse fields of the life sciences. Examples discussed in this article are the generation of spatial patterns in development by the interplay of autocatalysis and lateral inhibition; the evolution of integrating capabilities of the human brain, such as cognition-based empathy; and both neurobiological and epistemological aspects of scientific theories of consciousness and the mind.

Entities:  

Mesh:

Year:  2002        PMID: 12089469     DOI: 10.1007/bf02704909

Source DB:  PubMed          Journal:  J Biosci        ISSN: 0250-5991            Impact factor:   1.826


  16 in total

1.  Genomics and society. The human genome and our view of ourselves.

Authors:  S Pääbo
Journal:  Science       Date:  2001-02-16       Impact factor: 47.728

Review 2.  Pattern formation by local self-activation and lateral inhibition.

Authors:  H Meinhardt; A Gierer
Journal:  Bioessays       Date:  2000-08       Impact factor: 4.345

Review 3.  Recent duplication, domain accretion and the dynamic mutation of the human genome.

Authors:  E E Eichler
Journal:  Trends Genet       Date:  2001-11       Impact factor: 11.639

4.  Networks of gene regulation, neural development and the evolution of general capabilities, such as human empathy.

Authors:  A Gierer
Journal:  Z Naturforsch C J Biosci       Date:  1998 Jul-Aug

5.  A neuronal model of a global workspace in effortful cognitive tasks.

Authors:  S Dehaene; M Kerszberg; J P Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

6.  A bifurcation analysis of pattern formation in a diffusion governed morphogenetic field.

Authors:  M I Granero; A Porati; D Zanacca
Journal:  J Math Biol       Date:  1977-02-28       Impact factor: 2.259

7.  Generation and regeneration of sequence of structures during morphogenesis.

Authors:  H Meinhardt; A Gierer
Journal:  J Theor Biol       Date:  1980-08-07       Impact factor: 2.691

8.  Mirror neurons and the simulation theory of mind-reading.

Authors:  V Gallese; A Goldman
Journal:  Trends Cogn Sci       Date:  1998-12-01       Impact factor: 20.229

Review 9.  Theory of mind: evolutionary history of a cognitive specialization.

Authors:  D J Povinelli; T M Preuss
Journal:  Trends Neurosci       Date:  1995-09       Impact factor: 13.837

10.  Inhibition in the eye of Limulus.

Authors:  H K HARTLINE; H G WAGNER; F RATLIFF
Journal:  J Gen Physiol       Date:  1956-05-20       Impact factor: 4.086

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