| Literature DB >> 12088077 |
Deborah K Sokol1, David W Dunn, Mary Edwards-Brown, Judy Feinberg.
Abstract
Hydrogen proton magnetic resonance spectroscopy is only beginning to be studied in autistic individuals. We report an association between hydrogen proton magnetic resonance spectroscopy choline/creatine ratios and severity of autism as measured by the Children's Autistic Rating Scale (Pearson r = .657, P = .04) in 10 autistic children. Hydrogen proton magnetic resonance spectroscopy choline/creatine ratio measures the concentration of cytosolic choline including free choline used in the synthesis of acetylcholine. Elevation in this ratio has been interpreted as a result of membrane degradation such as caused by a tumor or, alternatively, as a result of choline synthesis associated with increased cellular proliferation. Recent neuropathologic evidence has implicated disruption of acetylcholine transmission in the brains of autistic adults. A case-controlled study of hydrogen proton magnetic resonance spectroscopy choline/creatine ratios is warranted.Entities:
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Year: 2002 PMID： 12088077 DOI： 10.1177/088307380201700401
Source DB: PubMed Journal: J Child Neurol ISSN： 0883-0738 Impact factor: 1.987