BACKGROUND AND PURPOSE: One former study reported higher prefrontal N-acetylaspartate (NAA) levels in patients with Asperger syndrome (AS). The objective of the current study was to test the hypothesis that patients with AS would have higher dorsolateral prefrontal and anterior cingulate cortex NAA/creatine (Cr) and that NAA/Cr would be correlated with symptom severity. MATERIALS AND METHODS: NAA/choline (Cho), NAA/Cr, and Cho/Cr values revealed by (1)H-MR spectroscopy in 14 right-handed male patients with AS (6 medicated with risperidone), 17-38 years of age, diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria were compared with those of 21 right-handed male controls frequency-matched by age and intelligence quotient scores. RESULTS: Patients with AS had significantly higher anterior cingulate NAA/Cho levels (z = -2.18, P = .028); there was a statistical trend for higher anterior cingulate NAA/Cr (z = -1.81, P = .069) that was significant when only the unmedicated patients with AS were taken into account (z = -1.95, P = .050). There were no significant differences in dorsolateral prefrontal MR spectroscopy values. CONCLUSIONS: Our findings show that individuals with AS had higher NAA/Cho levels in the right anterior cingulate compared with healthy controls and that higher anterior cingulate NAA/Cho levels were correlated with higher Yale-Brown Obsessive Compulsive Scale total scores.
BACKGROUND AND PURPOSE: One former study reported higher prefrontal N-acetylaspartate (NAA) levels in patients with Asperger syndrome (AS). The objective of the current study was to test the hypothesis that patients with AS would have higher dorsolateral prefrontal and anterior cingulate cortex NAA/creatine (Cr) and that NAA/Cr would be correlated with symptom severity. MATERIALS AND METHODS:NAA/choline (Cho), NAA/Cr, and Cho/Cr values revealed by (1)H-MR spectroscopy in 14 right-handed male patients with AS (6 medicated with risperidone), 17-38 years of age, diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria were compared with those of 21 right-handed male controls frequency-matched by age and intelligence quotient scores. RESULTS:Patients with AS had significantly higher anterior cingulate NAA/Cho levels (z = -2.18, P = .028); there was a statistical trend for higher anterior cingulate NAA/Cr (z = -1.81, P = .069) that was significant when only the unmedicated patients with AS were taken into account (z = -1.95, P = .050). There were no significant differences in dorsolateral prefrontal MR spectroscopy values. CONCLUSIONS: Our findings show that individuals with AS had higher NAA/Cho levels in the right anterior cingulate compared with healthy controls and that higher anterior cingulate NAA/Cho levels were correlated with higher Yale-Brown Obsessive Compulsive Scale total scores.
Authors: S Baron-Cohen; H A Ring; S Wheelwright; E T Bullmore; M J Brammer; A Simmons; S C Williams Journal: Eur J Neurosci Date: 1999-06 Impact factor: 3.386
Authors: T Hashimoto; N Kawano; K Fukuda; S Endo; K Mori; Y Yoneda; T Yamaue; M Harada; K Miyoshi Journal: Acta Neurol Scand Date: 1998-07 Impact factor: 3.209
Authors: C J McDougle; L E Kresch; W K Goodman; S T Naylor; F R Volkmar; D J Cohen; L H Price Journal: Am J Psychiatry Date: 1995-05 Impact factor: 18.112
Authors: L Tebartz van Elst; S Maier; T Fangmeier; D Endres; G T Mueller; K Nickel; D Ebert; T Lange; J Hennig; M Biscaldi; A Riedel; E Perlov Journal: Mol Psychiatry Date: 2014-07-22 Impact factor: 15.992
Authors: Hiroyuki Watanabe; Sylvia Fitting; Muhammad Z Hussain; Olga Kononenko; Anna Iatsyshyna; Takashi Yoshitake; Jan Kehr; Kanar Alkass; Henrik Druid; Henrik Wadensten; Per E Andren; Ingrid Nylander; Douglas H Wedell; Oleg Krishtal; Kurt F Hauser; Fred Nyberg; Victor M Karpyak; Tatjana Yakovleva; Georgy Bakalkin Journal: Cereb Cortex Date: 2013-08-19 Impact factor: 5.357
Authors: Y Aoki; O Abe; N Yahata; H Kuwabara; T Natsubori; N Iwashiro; Y Takano; H Inoue; Y Kawakubo; W Gonoi; H Sasaki; M Murakami; M Katsura; Y Nippashi; H Takao; A Kunimatsu; H Matsuzaki; K J Tsuchiya; N Kato; K Kasai; H Yamasue Journal: Transl Psychiatry Date: 2012-10-23 Impact factor: 6.222
Authors: Anthony Bejjani; Joseph O'Neill; John A Kim; Andrew J Frew; Victor W Yee; Ronald Ly; Christina Kitchen; Noriko Salamon; James T McCracken; Arthur W Toga; Jeffry R Alger; Jennifer G Levitt Journal: PLoS One Date: 2012-07-27 Impact factor: 3.240