Literature DB >> 12081153

Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.

Kenroh Sasaki1, Fumihiko Yoshizaki.   

Abstract

A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 microM) exhibited more potency than Kojic acid (IC50; 77.4 microM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.

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Year:  2002        PMID: 12081153     DOI: 10.1248/bpb.25.806

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN: 0918-6158            Impact factor:   2.233


  7 in total

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Review 7.  Phenolic compounds and biological activities of small-size citrus: Kumquat and calamondin.

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  7 in total

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