| Literature DB >> 12075079 |
Rachelle D Cook1,2, Tim A Hodgson2, Alastair C W Waugh2, Elizabeth M Molyneux3, Eric Borgstein3, A Sherry3, Chong Gee Teo1, Stephen R Porter2.
Abstract
To study transmission patterns of human herpesvirus-8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) in families in Malawi, nucleotide sequences derived from two hypervariable loci of the HHV-8 genome, the V1 and V2 regions of open reading frame K1 (K1/V1 and K1/V2, respectively), were amplified from blood and mouth rinse samples of 22 patients with treated and untreated Kaposi's sarcoma (KS) and their first-degree relatives (n=67). In patients with KS, vincristine therapy was significantly associated with non-detectability of circulating, but not oral, K1/V1 DNA. Intra-familial K1/V1 phylogenetic comparisons of eight families were possible. Both identical and non-identical sequences were observed between family members, suggesting transmission of HHV-8 along both intra- and extra-familial transmission routes.Entities:
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Year: 2002 PMID： 12075079 DOI： 10.1099/0022-1317-83-7-1613
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891