Kristian Løvås1, Eystein S Husebye. 1. Division of Endocrinology, Institute of Medicine, Haukeland University Hospital, Bergen, Norway. kristian.lovas@haukeland.no
Abstract
OBJECTIVE: Estimates of the prevalence of Addison's disease in Caucasians have varied from 39 to 117 per million. We have carried out an epidemiological study to obtain a confident point prevalence estimate in the Norwegian population for the end of 1999, and to find out whether the incidence is changing. PATIENTS AND METHODS: The patients were identified by a search through registers of 10 hospitals and consultant endocrinologists serving a population of 916 000. The completeness of the list was tested by a survey of general practitioners in one district, and by the member list of the local Addison Association in another district. RESULTS: We identified 128 patients with Addison's disease (59 men and 69 women), yielding a prevalence of 140 per million. Recorded mean incidence in the past decade was 0.62 per 100,000 per year. Fifty-one patients (40%) had concomitant endocrine diseases. The aetiology was almost exclusively idiopathic or autoimmune. CONCLUSIONS: We found a higher prevalence of Addison's disease in western Norway than has previously been reported anywhere. Our findings support the hypothesis of a rising incidence of autoimmune adrenal insufficiency.
OBJECTIVE: Estimates of the prevalence of Addison's disease in Caucasians have varied from 39 to 117 per million. We have carried out an epidemiological study to obtain a confident point prevalence estimate in the Norwegian population for the end of 1999, and to find out whether the incidence is changing. PATIENTS AND METHODS: The patients were identified by a search through registers of 10 hospitals and consultant endocrinologists serving a population of 916 000. The completeness of the list was tested by a survey of general practitioners in one district, and by the member list of the local Addison Association in another district. RESULTS: We identified 128 patients with Addison's disease (59 men and 69 women), yielding a prevalence of 140 per million. Recorded mean incidence in the past decade was 0.62 per 100,000 per year. Fifty-one patients (40%) had concomitant endocrine diseases. The aetiology was almost exclusively idiopathic or autoimmune. CONCLUSIONS: We found a higher prevalence of Addison's disease in western Norway than has previously been reported anywhere. Our findings support the hypothesis of a rising incidence of autoimmune adrenal insufficiency.
Authors: Lalantha Leelarathna; Louise Breen; James K Powrie; Stephen M Thomas; Rustom Guzder; Barbara McGowan; Paul V Carroll Journal: Endocrine Date: 2010-07-03 Impact factor: 3.633
Authors: A M Isidori; G Arnaldi; M Boscaro; A Falorni; C Giordano; R Giordano; R Pivonello; C Pozza; E Sbardella; C Simeoli; C Scaroni; A Lenzi Journal: J Endocrinol Invest Date: 2019-11-26 Impact factor: 4.256