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Literature DB >> 12069987

Fluorescence assay for studying the ability of macrolides to induce production of ribosomal methylase.

Abstract

A screening assay to test the inducing capacity of macrolides by fusing the attenuator of the inducible erm(B) gene from Streptococcus pneumoniae HM28 with the gfpmut1 gene has been designed. Fluorescence was detected under UV light around disks impregnated with inducer macrolides (erythromycin or azithromycin) but not with noninducer ketolides. Induction could be quantified by fluorometry.

Entities: Chemical Species

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Year: 2002 PMID： 12069987 PMCID： PMC127294 DOI： 10.1128/AAC.46.7.2269-2272.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

Review 1. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors: M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal: Antimicrob Agents Chemother Date: 1999-12 Impact factor: 5.191

2. Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin.

Authors: A Rosato; H Vicarini; R Leclercq
Journal: J Antimicrob Chemother Date: 1999-04 Impact factor: 5.790

3. A pair of mobilizable shuttle vectors conferring resistance to spectinomycin for molecular cloning in Escherichia coli and in gram-positive bacteria.

Authors: P Trieu-Cuot; C Carlier; C Poyart-Salmeron; P Courvalin
Journal: Nucleic Acids Res Date: 1990-07-25 Impact factor: 16.971

4. Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens.

Authors: A Denis; C Agouridas; J M Auger; Y Benedetti; A Bonnefoy; F Bretin; J F Chantot; A Dussarat; C Fromentin; S G D'Ambrières; S Lachaud; P Laurin; O Le Martret; V Loyau; N Tessot; J M Pejac; S Perron
Journal: Bioorg Med Chem Lett Date: 1999-11-01 Impact factor: 2.823

5. Beta-keto-ester chemistry and ketolides. Synthesis and antibacterial activity of 2-halogeno, 2-methyl and 2,3 enol-ether ketolides.

Authors: A Denis; F Bretin; C Fromentin; A Bonnet; G Piltan; A Bonnefoy; C Agouridas
Journal: Bioorg Med Chem Lett Date: 2000-09-04 Impact factor: 2.823

6. Binding of novel macrolide structures to macrolides-lincosamides-streptogramin B-resistant ribosomes inhibits protein synthesis and bacterial growth.

Authors: R C Goldman; S K Kadam
Journal: Antimicrob Agents Chemother Date: 1989-07 Impact factor: 5.191

7. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA.

Authors: S Douthwaite; L H Hansen; P Mauvais
Journal: Mol Microbiol Date: 2000-04 Impact factor: 3.501

Review 8. Ketolides-telithromycin, an example of a new class of antibacterial agents.

Authors: A Bryskier
Journal: Clin Microbiol Infect Date: 2000-12 Impact factor: 8.067

9. A complex attenuator regulates inducible resistance to macrolides, lincosamides, and streptogramin type B antibiotics in Streptococcus sanguis.

Authors: S Horinouchi; W H Byeon; B Weisblum
Journal: J Bacteriol Date: 1983-06 Impact factor: 3.490

10. Constitutive expression of erythromycin resistance mediated by the ermAM determinant of plasmid pAM beta 1 results from deletion of 5' leader peptide sequences.

Authors: B Martin; G Alloing; V Méjean; J P Claverys
Journal: Plasmid Date: 1987-11 Impact factor: 3.466

5 in total

1. Attenuation-based dual-fluorescent-protein reporter for screening translation inhibitors.

Authors: Ilya A Osterman; Irina V Prokhorova; Vasily O Sysoev; Yulia V Boykova; Olga V Efremenkova; Maxim S Svetlov; Vyacheslav A Kolb; Alexey A Bogdanov; Petr V Sergiev; Olga A Dontsova
Journal: Antimicrob Agents Chemother Date: 2012-01-17 Impact factor: 5.191