| Literature DB >> 12069781 |
Gilles Labesse1, Dominique Douguet, Liliane Assairi, Anne Marie Gilles.
Abstract
Diacylglyceride kinases, sphingosine kinases, NAD kinases and 6-phosphofructokinases are thought to be related despite large evolution of their sequences. Discovery of a common signature has led to the suggestion that they possess a similar phosphate-donor-binding site and a similar phosphorylation mechanism. The substrate- and allosteric-binding sites are much more divergent and their delineation remains to be determined experimentally.Entities:
Mesh:
Substances:
Year: 2002 PMID: 12069781 DOI: 10.1016/s0968-0004(02)02093-5
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807