Literature DB >> 12065789

Interpreting measures of treatment effect in cancer clinical trials.

L Douglas Case1, Gretchen Kimmick, Electra D Paskett, Kurt Lohman, Robert Tucker.   

Abstract

The efficacy of a new cancer regimen is usually assessed by analyzing outcomes such as tumor response and overall survival. Many publications summarizing results of cancer clinical trials report measures such as odds ratios and hazard ratios, as these are the estimators of treatment effect obtained from regression models used to analyze the data. However, these measures are sometimes misinterpreted, as they are not necessarily familiar to many readers. The most common mistake is to interpret both measures as relative risks, an interpretation that can lead to an incorrect impression of the impact of the treatment on response and survival.

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Year:  2002        PMID: 12065789     DOI: 10.1634/theoncologist.7-3-181

Source DB:  PubMed          Journal:  Oncologist        ISSN: 1083-7159


  26 in total

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3.  On the Interpretation of the Hazard Ratio and Communication of Survival Benefit.

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Journal:  Oncologist       Date:  2017-03-17

4.  Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials.

Authors:  Federica Cuppone; Emilio Bria; Vanja Vaccaro; Fabio Puglisi; Alessandra Fabi; Isabella Sperduti; Paolo Carlini; Michele Milella; Cecilia Nisticò; Michelangelo Russillo; Paola Papaldo; Gianluigi Ferretti; Matti Aapro; Diana Giannarelli; Francesco Cognetti
Journal:  J Exp Clin Cancer Res       Date:  2011-05-12

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6.  A literature-based meta-analysis taxane-based doublet versus single-agent taxane chemotherapy in patients with advanced breast cancer.

Authors:  Hong-Bin Xu; Qing Xu; Ling Li
Journal:  J Cancer Res Clin Oncol       Date:  2010-12-18       Impact factor: 4.553

7.  Design of non-inferiority randomized trials using the difference in restricted mean survival times.

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Journal:  Clin Trials       Date:  2018-08-03       Impact factor: 2.486

Review 8.  Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach.

Authors:  F Richy; O Bruyere; O Ethgen; V Rabenda; G Bouvenot; M Audran; G Herrero-Beaumont; A Moore; R Eliakim; M Haim; J-Y Reginster
Journal:  Ann Rheum Dis       Date:  2004-07       Impact factor: 19.103

9.  Are reading and behavior problems risk factors for each other?

Authors:  Paul L Morgan; George Farkas; Paula A Tufis; Rayne A Sperling
Journal:  J Learn Disabil       Date:  2008 Sep-Oct

Review 10.  Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?

Authors:  Chen Sun; Daniel Ansari; Roland Andersson; De-Quan Wu
Journal:  World J Gastroenterol       Date:  2012-09-21       Impact factor: 5.742

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