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Literature DB >> 12065546

Molecular cloning of a vaccine antigen against infection with the larval stage of Echinococcus multilocularis.

Charles Gauci¹, Michael Merli, Volker Muller, Conan Chow, Kinpei Yagi, Ute Mackenstedt, Marshall W Lightowlers.

Abstract

Alveolar and cystic hydatidosis are caused by infection with the larval stages of Echinococcus multilocularis and Echinococcus granulosus, respectively. A host-protective antigen has been identified in E. granulosus. Here we identify the presence of a closely related protein in E. multilocularis, characterize and express a cDNA encoding the antigen (designated EM95), determine the structure of the em95 gene, and demonstrate that the EM95 recombinant protein can be used to induce significant levels of protection against challenge infection with E. multilocularis eggs in mice.

Entities: Disease Species

Mesh：

Substances：

Year: 2002 PMID： 12065546 PMCID： PMC128094 DOI： 10.1128/IAI.70.7.3969-3972.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

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Journal: Parasite Immunol Date: 1996-09 Impact factor: 2.280

2. SMART: identification and annotation of domains from signalling and extracellular protein sequences.

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3. Epitope specificities and antibody responses to the EG95 hydatid vaccine.

Authors: D J Woollard; C G Gauci; D D Heath; M W Lightowlers
Journal: Parasite Immunol Date: 1998-11 Impact factor: 2.280

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Journal: Nucleic Acids Res Date: 1997-09-01 Impact factor: 16.971

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Journal: Mol Biochem Parasitol Date: 1997-05 Impact factor: 1.759

6. Characterization of the gene family encoding a host-protective antigen of the tapeworm Taenia ovis.

Authors: J G Waterkeyn; M W Lightowlers; R Coppel; A F Cowman
Journal: Mol Biochem Parasitol Date: 1995-07 Impact factor: 1.759

7. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

Authors: J D Thompson; D G Higgins; T J Gibson
Journal: Nucleic Acids Res Date: 1994-11-11 Impact factor: 16.971

8. Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep.

Authors: M W Lightowlers; O Jensen; E Fernandez; J A Iriarte; D J Woollard; C G Gauci; D J Jenkins; D D Heath
Journal: Int J Parasitol Date: 1999-04 Impact factor: 3.981

9. Taenia saginata: vaccination against cysticercosis in cattle with recombinant oncosphere antigens.

Authors: M W Lightowlers; R Rolfe; C G Gauci
Journal: Exp Parasitol Date: 1996-12 Impact factor: 2.011

10. A knowledge base for predicting protein localization sites in eukaryotic cells.

Authors: K Nakai; M Kanehisa
Journal: Genomics Date: 1992-12 Impact factor: 5.736

15 in total

1. Analysis of cDNAs coding for immunologically dominant antigens from an oncosphere-specific cDNA library of Echinococcus multilocularis.

Authors: Armin Merckelbach; Martina Wager; Richard Lucius
Journal: Parasitol Res Date: 2003-06-26 Impact factor: 2.289

2. Molecular and functional characterization of a Taenia adhesion gene family (TAF) encoding potential protective antigens of Taenia saginata oncospheres.

Authors: Luis Miguel Gonzalez; Pedro Bonay; Laura Benitez; Elizabeth Ferrer; Leslie J S Harrison; R Michael E Parkhouse; Teresa Garate
Journal: Parasitol Res Date: 2006-10-18 Impact factor: 2.289

Review 3. The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction.

Authors: Klaus Brehm
Journal: Med Microbiol Immunol Date: 2010-04-08 Impact factor: 3.402

4. Serological Assays for Alveolar and Cystic Echinococcosis-A Comparative Multi-Test Study in Switzerland and Kyrgyzstan.

Authors: Philipp A Kronenberg; Ansgar Deibel; Bruno Gottstein; Felix Grimm; Beat Müllhaupt; Cordula Meyer Zu Schwabedissen; Sezdbek Aitbaev; Rakhatbek A Omorov; Kubanychbek K Abdykerimov; Gulnara Minbaeva; Jumagul Usubalieva; Mar Siles-Lucas; Paola Pepe; Laura Rinaldi; Markus Spiliotis; Junhua Wang; Norbert Müller; Paul R Torgerson; Peter Deplazes
Journal: Pathogens Date: 2022-04-27

Review 5. Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay.

Authors: Dominique Angèle Vuitton; Bruno Gottstein
Journal: J Biomed Biotechnol Date: 2010-03-21

6. Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs.

Authors: Bruno Gottstein; Matthias Wittwer; Marc Schild; Michael Merli; Stephen L Leib; Norbert Müller; Joachim Müller; Rolf Jaggi
Journal: PLoS One Date: 2010-04-01 Impact factor: 3.240

Review 7. Concepts in immunology and diagnosis of hydatid disease.

Authors: Wenbao Zhang; Jun Li; Donald P McManus
Journal: Clin Microbiol Rev Date: 2003-01 Impact factor: 26.132

8. The EG95 antigen of Echinococcus spp. contains positively selected amino acids, which may influence host specificity and vaccine efficacy.

Authors: Karen Luisa Haag; Bruno Gottstein; Francisco Jose Ayala
Journal: PLoS One Date: 2009-04-29 Impact factor: 3.240

9. Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen.

Authors: Ghalia Boubaker; Andrew Hemphill; Cristina Olivia Huber; Markus Spiliotis; Hamouda Babba; Bruno Gottstein
Journal: PLoS Negl Trop Dis Date: 2015-06-08

10. Analysis on Gene Expression Profile in Oncospheres and Early Stage Metacestodes from Echinococcus multilocularis.

Authors: Fuqiang Huang; Zhisheng Dang; Yutaka Suzuki; Terumi Horiuchi; Kinpei Yagi; Hirokazu Kouguchi; Takao Irie; Kyeongsoon Kim; Yuzaburo Oku
Journal: PLoS Negl Trop Dis Date: 2016-04-19