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Literature DB >> 12065539

Purified malaria pigment (hemozoin) enhances dendritic cell maturation and modulates the isotype of antibodies induced by a DNA vaccine.

Cevayir Coban¹, Ken J Ishii, David J Sullivan, Nirbhay Kumar.

Abstract

Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a Plasmodium falciparum transmission-blocking antigen.

Entities: Disease Species

Mesh：

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Year: 2002 PMID： 12065539 PMCID： PMC128057 DOI： 10.1128/IAI.70.7.3939-3943.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

26 in total

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Journal: Infect Immun Date: 1999-04 Impact factor: 3.441

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25 in total

Review 1. Toll or toll-free adjuvant path toward the optimal vaccine development.

Authors: Ken J Ishii; Shizuo Akira
Journal: J Clin Immunol Date: 2007-03-17 Impact factor: 8.317

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Authors: Takahiro Tougan; Taiki Aoshi; Cevayir Coban; Yuko Katakai; Chieko Kai; Yasuhiro Yasutomi; Ken J Ishii; Toshihiro Horii
Journal: Hum Vaccin Immunother Date: 2013-01-04 Impact factor: 3.452

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Authors: Christopher C Keller; Ouma Yamo; Collins Ouma; John Michael Ong'echa; David Ounah; James B Hittner; John M Vulule; Douglas J Perkins
Journal: Infect Immun Date: 2006-09 Impact factor: 3.441

4. Effect of CpG oligodeoxynucleotides on the immunogenicity of Pfs25, a Plasmodium falciparum transmission-blocking vaccine antigen.

Authors: Cevayir Coban; Ken J Ishii; Anthony W Stowers; David B Keister; Dennis M Klinman; Nirbhay Kumar
Journal: Infect Immun Date: 2004-01 Impact factor: 3.441

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Journal: Infect Immun Date: 2004-01 Impact factor: 3.441

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Journal: Parasite Immunol Date: 2009-02 Impact factor: 2.280