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Literature DB >> 18071705

Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria.

Catherine Ropert¹, Bernardo S Franklin, Ricardo T Gazzinelli.

Abstract

Toll-like receptors (TLRs) are important to initiate the innate immune response to a wide variety of pathogens. The protective role of TLRs during infection with protozoan parasites has been established. In this regard, malaria represents an exception where activation of TLRs seems to be deleterious to the host. In this article, we review the recent findings indicating the contrasting role of Myeloid Differentiation Primary-Response gene 88 (MyD88) and TLRs during malaria and infection with other protozoa. These findings suggest that MyD88 may represent an Achilles' heel during Plasmodium infection.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 18071705 DOI： 10.1007/s00281-007-0103-2

Source DB: PubMed Journal: Semin Immunopathol ISSN： 1863-2297 Impact factor: 9.623

96 in total

1. A Toll-like receptor recognizes bacterial DNA.

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Journal: Nature Date: 2000-12-07 Impact factor: 49.962

2. Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.

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Journal: Am J Pathol Date: 2001-11 Impact factor: 4.307

3. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

Authors: T M Scharton-Kersten; T A Wynn; E Y Denkers; S Bala; E Grunvald; S Hieny; R T Gazzinelli; A Sher
Journal: J Immunol Date: 1996-11-01 Impact factor: 5.422

Review 4. Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data.

Authors: G E Grau; P F Piguet; P Vassalli; P H Lambert
Journal: Immunol Rev Date: 1989-12 Impact factor: 12.988

5. Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide.

Authors: C Ropert; I C Almeida; M Closel; L R Travassos; M A Ferguson; P Cohen; R T Gazzinelli
Journal: J Immunol Date: 2001-03-01 Impact factor: 5.422

6. Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.

Authors: F P Mockenhaupt; J P Cramer; L Hamann; M S Stegemann; J Eckert; Na-Ri Oh; R N Otchwemah; E Dietz; S Ehrhardt; N W J Schröder; U Bienzle; R R Schumann
Journal: J Commun Dis Date: 2006-03

7. Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.

Authors: Christian F Ockenhouse; Wan-chung Hu; Kent E Kester; James F Cummings; Ann Stewart; D Gray Heppner; Anne E Jedlicka; Alan L Scott; Nathan D Wolfe; Maryanne Vahey; Donald S Burke
Journal: Infect Immun Date: 2006-10 Impact factor: 3.441

8. Cerebral malaria in children: serum and cerebrospinal fluid TNF-alpha and TGF-beta levels and their relationship to clinical outcome.

Authors: Fabian Esamai; Jan Ernerudh; Helena Janols; Susanne Welin; Christina Ekerfelt; Simeon Mining; Pia Forsberg
Journal: J Trop Pediatr Date: 2003-08 Impact factor: 1.165

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Journal: J Cell Sci Date: 1999-09 Impact factor: 5.285

10. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.

Authors: L Schofield; F Hackett
Journal: J Exp Med Date: 1993-01-01 Impact factor: 14.307

17 in total

1. Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice.

Authors: Diane Tshikudi Malu; Benoit Bélanger; François Desautels; Karine Kelendji; Esther Dalko; Jaime Sanchez-Dardon; Lin Leng; Richard Bucala; Abhay R Satoskar; Tatiana Scorza
Journal: J Immunol Date: 2011-04-25 Impact factor: 5.422

Review 2. Parasite virulence, co-infections and cytokine balance in malaria.

Authors: Raquel Müller Gonçalves; Nathália Ferreira Lima; Marcelo Urbano Ferreira
Journal: Pathog Glob Health Date: 2014-05-23 Impact factor: 2.894

3. MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis.

Authors: Bibhuti B Mishra; Uma Mahesh Gundra; Kondi Wong; Judy M Teale
Journal: Infect Immun Date: 2009-09-28 Impact factor: 3.441

Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria.

1. A Toll-like receptor recognizes bacterial DNA.

2. Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.

3. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

Review 4. Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data.

6. Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.

7. Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.

8. Cerebral malaria in children: serum and cerebrospinal fluid TNF-alpha and TGF-beta levels and their relationship to clinical outcome.

Review 9. The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.

10. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.

1. Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice.

Review 2. Parasite virulence, co-infections and cytokine balance in malaria.

3. MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis.

Review 4. The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.

Review 5. Toll-like receptor signaling pathways--therapeutic opportunities.

6. An Atypical Splenic B Cell Progenitor Population Supports Antibody Production during Plasmodium Infection in Mice.

7. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria.

8. Comparative genomics of Toll-like receptor signalling in five species.

9. Identification of potential pathway mediation targets in Toll-like receptor signaling.

Review 10. Toll-like receptor initiated host defense against Toxoplasma gondii.