| Literature DB >> 12062500 |
E Adams1, D Coomans, J Smeyers-Verbeke, D L Massart.
Abstract
The use of non-linear mixed effects models to describe dissolution data has been evaluated. A theoretical part is included to introduce this approach to scientists who are not familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several mathematical functions like the Weibull, logistic, first-order and Gompertz are employed as basis for the non-linear mixed effects models. Examples are given using dissolution data of immediate and extended release tablets. The results are compared with those obtained using linear mixed effects models.Mesh：
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Year: 2002 PMID： 12062500 DOI： 10.1016/s0378-5173(02)00127-8
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875